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Defective monocyte-derived macrophage phagocytosis is associated with exacerbation frequency in COPD

BACKGROUND: Lower airway bacterial colonisation (LABC) in COPD patients is associated with increased exacerbation frequency and faster lung function decline. Defective macrophage phagocytosis in COPD drives inflammation, but how defective macrophage function contributes to exacerbations is not clear...

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Detalles Bibliográficos
Autores principales: Singh, R., Belchamber, K. B. R., Fenwick, P. S., Chana, K., Donaldson, G., Wedzicha, J. A., Barnes, P. J., Donnelly, L. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8059282/
https://www.ncbi.nlm.nih.gov/pubmed/33879129
http://dx.doi.org/10.1186/s12931-021-01718-8