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Metamorphic proteins: the Janus proteins of structural biology

The structural paradigm that the sequence of a protein encodes for a unique three-dimensional native fold does not acknowledge the intrinsic plasticity encapsulated in conformational free energy landscapes. Metamorphic proteins are a recently discovered class of biomolecules that illustrate this pla...

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Detalles Bibliográficos
Autores principales: Madhurima, Kulkarni, Nandi, Bodhisatwa, Sekhar, Ashok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8059507/
https://www.ncbi.nlm.nih.gov/pubmed/33878950
http://dx.doi.org/10.1098/rsob.210012