Cargando…

MET-Pyk2 Axis Mediates Acquired Resistance to FGFR Inhibition in Cancer Cells

Deregulation of fibroblast growth factor receptors (FGFRs) signaling, as a result of FGFR amplification, chromosomal translocation, or mutations, is involved in both initiation and progression of a wide range of human cancers. Clinical data demonstrating the dependence of cancer cells on FGFRs signa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kitowska, Kamila, Gorska-Arcisz, Monika, Antoun, Dima, Zarczynska, Izabela, Czaplinska, Dominika, Szczepaniak, Adrian, Skladanowski, Andrzej C., Wieczorek, Maciej, Stanczak, Aleksandra, Skupinska, Monika, Sadej, Rafal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8059549/ https://www.ncbi.nlm.nih.gov/pubmed/33898310 http://dx.doi.org/10.3389/fonc.2021.633410

Ejemplares similares

p38 Mediates Resistance to FGFR Inhibition in Non-Small Cell Lung Cancer
por: Zarczynska, Izabela, et al.
Publicado: (2021)

FGFR2-Driven Signaling Counteracts Tamoxifen Effect on ERα-Positive Breast Cancer Cells
por: Turczyk, Lukasz, et al.
Publicado: (2017)

FGF7/FGFR2–JunB signalling counteracts the effect of progesterone in luminal breast cancer
por: Mieczkowski, Kamil, et al.
Publicado: (2022)

Interactions between FGFR2 and RSK2—implications for breast cancer prognosis
por: Czaplinska, Dominika, et al.
Publicado: (2016)

Fibroblast growth factor signalling induces loss of progesterone receptor in breast cancer cells
por: Piasecka, Dominika, et al.
Publicado: (2016)

FGFR2 Controls Growth, Adhesion and Migration of Nontumorigenic Human Mammary Epithelial Cells by Regulation of Integrin β1 Degradation
por: Mieczkowski, Kamil, et al.
Publicado: (2023)

FGFs/FGFRs-dependent signalling in regulation of steroid hormone receptors – implications for therapy of luminal breast cancer
por: Piasecka, Dominika, et al.
Publicado: (2019)

FGFR1–4 RNA-Based Gene Alteration and Expression Analysis in Squamous Non-Small Cell Lung Cancer
por: Moes-Sosnowska, Joanna, et al.
Publicado: (2022)

A ‘Real-Life’ Experience on Automated Digital Image Analysis of FGFR2 Immunohistochemistry in Breast Cancer
por: Braun, Marcin, et al.
Publicado: (2020)

Epithelial–mesenchymal transition confers resistance to selective FGFR inhibitors in SNU-16 gastric cancer cells
por: Grygielewicz, Paulina, et al.
Publicado: (2014)

Hormonal Receptor Status Determines Prognostic Significance of FGFR2 in Invasive Breast Carcinoma
por: Braun, Marcin, et al.
Publicado: (2020)

Silica-Polymer Composites as the Novel Antibiotic Delivery Systems for Bone Tissue Infection
por: Skwira, Adrianna, et al.
Publicado: (2019)

Pyk2 for perfect bones
por: LeBrasseur, Nicole
Publicado: (2007)

Activation of the Met kinase confers acquired drug resistance in FGFR-targeted lung cancer therapy
por: Kim, S-M, et al.
Publicado: (2016)

Role of Pyk2 in Human Cancers
por: Shen, Ting, et al.
Publicado: (2018)

Impact of the Whole Genome Duplication Event on PYK Activity and Effects of a PYK1 Mutation on Metabolism in S. cerevisiae
por: Chen, Hong, et al.
Publicado: (2021)

Systems modelling of the EGFR-PYK2-c-Met interaction network predicts and prioritizes synergistic drug combinations for triple-negative breast cancer
por: Shin, Sung-Young, et al.
Publicado: (2018)

Overexpression of FGFR2 contributes to inherent resistance to MET inhibitors in MET-amplified patient-derived gastric cancer xenografts
por: LIU, KAI, et al.
Publicado: (2015)

Co-dependency for MET and FGFR1 in basal triple-negative breast cancers
por: Sung, Vanessa Y. C., et al.
Publicado: (2021)

Novel Role of Src in Priming Pyk2 Phosphorylation
por: Zhao, Ming, et al.
Publicado: (2016)

Convergent Effects of Resveratrol and PYK2 on Prostate Cells
por: Conte, Andrea, et al.
Publicado: (2016)

PYK2 at the Intersection of Signaling Pathways in Pancreatic Cancer
por: Means, Anna L.
Publicado: (2019)

H2AX Phosphorylation: Its Role in DNA Damage Response and Cancer Therapy
por: Podhorecka, Monika, et al.
Publicado: (2010)

MicroRNAs in regulation of triple-negative breast cancer progression
por: Piasecka, Dominika, et al.
Publicado: (2018)

FGF/FGFR-Dependent Molecular Mechanisms Underlying Anti-Cancer Drug Resistance
por: Szymczyk, Jakub, et al.
Publicado: (2021)

Deep analysis of acquired resistance to FGFR1 inhibitor identifies MET and AKT activation and an expansion of AKT1 mutant cells
por: Gimenez-Xavier, Pol, et al.
Publicado: (2018)

Suppression of Pyk2 Kinase and Cellular Activities by Fip200
por: Ueda, Hiroki, et al.
Publicado: (2000)

Pyk2 promotes tumor progression in renal cell carcinoma
por: Zhao, Tangliang, et al.
Publicado: (2018)

Pyk2 Regulates MAMs and Mitochondrial Dynamics in Hippocampal Neurons
por: López-Molina, Laura, et al.
Publicado: (2022)

Higher Levels of Low Molecular Weight Sulfur Compounds and Homocysteine Thiolactone in the Urine of Autistic Children
por: Gątarek, Paulina, et al.
Publicado: (2020)

Gene amplification of EGFR, HER2, FGFR2 and MET in esophageal squamous cell carcinoma
por: KATO, HIROAKI, et al.
Publicado: (2013)

Prognostic Significance of Wnt-1, β-catenin and E-cadherin Expression in Advanced Colorectal Carcinoma
por: Stanczak, Aleksandra, et al.
Publicado: (2011)

Hematopoietic Pyk2 regulates migration of differentiated HL-60 cells
por: Wang, Lin, et al.
Publicado: (2010)

Endogenous Control Mechanisms of FAK and PYK2 and Their Relevance to Cancer Development
por: Naser, Rayan, et al.
Publicado: (2018)

Non-redundant functions of FAK and Pyk2 in intestinal epithelial repair
por: Thomas, Keena S., et al.
Publicado: (2019)

PYK2 promotes HER2-positive breast cancer invasion
por: Al-Juboori, Shaymaa IK., et al.
Publicado: (2019)

Pyk2 regulates cell-edge protrusion dynamics by interacting with Crk
por: Lukic, Nikola, et al.
Publicado: (2021)

Pyk2/MCU Pathway as a New Target for Reversing Atherosclerosis
por: Zhang, Yingzhen, et al.
Publicado: (2021)

Pyk2 suppresses contextual fear memory in an autophosphorylation-independent manner
por: Zheng, Jin, et al.
Publicado: (2021)

Pyk2 regulates sepsis-induced lung injury via ferroptosis
por: Wang, Jia, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_pnr2tf74a692ns0cc57dtls1io