Genetic association and causal inference converge on hyperglycaemia as a modifiable factor to improve lung function

Measures of lung function are heritable, and thus, we sought to utilise genetics to propose drug-repurposing candidates that could improve respiratory outcomes. Lung function measures were found to be genetically correlated with seven druggable biochemical traits, with further evidence of a causal r...

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Detalles Bibliográficos
Autores principales: Reay, William R, El Shair, Sahar I, Geaghan, Michael P, Riveros, Carlos, Holliday, Elizabeth G, McEvoy, Mark A, Hancock, Stephen, Peel, Roseanne, Scott, Rodney J, Attia, John R, Cairns, Murray J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8060032/
https://www.ncbi.nlm.nih.gov/pubmed/33720009
http://dx.doi.org/10.7554/eLife.63115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8060032/
https://www.ncbi.nlm.nih.gov/pubmed/33720009
http://dx.doi.org/10.7554/eLife.63115

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