Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair

How adhesive forces are transduced and integrated into biochemical signals at focal adhesions (FAs) is poorly understood. Using cells adhering to deformable micropillar arrays, we demonstrate that traction force and FAK localization as well as traction force and Y397-FAK phosphorylation are linearly...

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Detalles Bibliográficos
Autores principales: Zhou, Dennis W., Fernández-Yagüe, Marc A., Holland, Elijah N., García, Andrés F., Castro, Nicolas S., O’Neill, Eric B., Eyckmans, Jeroen, Chen, Christopher S., Fu, Jianping, Schlaepfer, David D., García, Andrés J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8060400/
https://www.ncbi.nlm.nih.gov/pubmed/33883558
http://dx.doi.org/10.1038/s41467-021-22602-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8060400/
https://www.ncbi.nlm.nih.gov/pubmed/33883558
http://dx.doi.org/10.1038/s41467-021-22602-5

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