Transcriptomic analysis of immune cells in a multi-ethnic cohort of systemic lupus erythematosus patients identifies ethnicity- and disease-specific expression signatures

Systemic lupus erythematosus (SLE) is an autoimmune disease in which outcomes vary among different racial groups. We leverage cell-sorted RNA-seq data (CD14+ monocytes, B cells, CD4+ T cells, and NK cells) from 120 SLE patients (63 Asian and 57 White individuals) and apply a four-tier approach inclu...

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Detalles Bibliográficos
Autores principales: Andreoletti, Gaia, Lanata, Cristina M., Trupin, Laura, Paranjpe, Ishan, Jain, Tia S., Nititham, Joanne, Taylor, Kimberly E., Combes, Alexis J., Maliskova, Lenka, Ye, Chun Jimmie, Katz, Patricia, Dall’Era, Maria, Yazdany, Jinoos, Criswell, Lindsey A., Sirota, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8060402/
https://www.ncbi.nlm.nih.gov/pubmed/33883687
http://dx.doi.org/10.1038/s42003-021-02000-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8060402/
https://www.ncbi.nlm.nih.gov/pubmed/33883687
http://dx.doi.org/10.1038/s42003-021-02000-9

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