Cargando…

Fiber Derived Microbial Metabolites Prevent Acute Kidney Injury Through G-Protein Coupled Receptors and HDAC Inhibition

Short-chain fatty acids (SCFA) derived from gut microbial fermentation of fiber have been shown to exert anti-inflammatory and immune-modulatory properties in acute kidney injury (AKI). However the direct mechanistic link between SCFAs, diet and the gut microbiome is yet to be established. Using the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Yunzi, Li, Yan J., Loh, Yik W., Singer, Julian, Zhu, Weiping, Macia, Laurence, Mackay, Charles R., Wang, Weiming, Chadban, Steven J., Wu, Huiling
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8060457/ https://www.ncbi.nlm.nih.gov/pubmed/33898439 http://dx.doi.org/10.3389/fcell.2021.648639

Ejemplares similares

Short-chain fatty acids directly exert anti-inflammatory responses in podocytes and tubular epithelial cells exposed to high glucose
por: Li, Yan Jun, et al.
Publicado: (2023)

The Role of HDACs and HDACi in Cartilage and Osteoarthritis
por: Zhang, He, et al.
Publicado: (2020)

Recent Update of HDAC Inhibitors in Lymphoma
por: Chen, I-Chung, et al.
Publicado: (2020)

HDAC Inhibitor Titration of Transcription and Axolotl Tail Regeneration
por: Voss, S. Randal, et al.
Publicado: (2021)

Histone Deacetylases (HDACs) and Atherosclerosis: A Mechanistic and Pharmacological Review
por: Chen, Xiaona, et al.
Publicado: (2020)

Role of HDAC6 and Its Selective Inhibitors in Gastrointestinal Cancer
por: Zhou, Bingyi, et al.
Publicado: (2021)

Integrated Analysis Reveals the Gut Microbial Metabolite TMAO Promotes Inflammatory Hepatocellular Carcinoma by Upregulating POSTN
por: Wu, Yonglin, et al.
Publicado: (2022)

HDAC8: A Promising Therapeutic Target for Acute Myeloid Leukemia
por: Spreafico, Marco, et al.
Publicado: (2020)

HDAC6 Regulates the Fusion of Autophagosome and Lysosome to Involve in Odontoblast Differentiation
por: Zhan, Yunyan, et al.
Publicado: (2020)

The Role of HDAC6 in TDP-43-Induced Neurotoxicity and UPS Impairment
por: Lee, Shinrye, et al.
Publicado: (2020)

MCM5 Aggravates the HDAC1-Mediated Malignant Progression of Lung Cancer
por: Zhang, Lin-lin, et al.
Publicado: (2021)

Tau-dependent HDAC1 nuclear reduction is associated with altered VGluT1 expression
por: Siano, Giacomo, et al.
Publicado: (2023)

Loss of Deacetylation Enzymes Hdac6 and Sirt2 Promotes Acetylation of Cytoplasmic Tubulin, but Suppresses Axonemal Acetylation in Zebrafish Cilia
por: Łysyganicz, Paweł K., et al.
Publicado: (2021)

Protocol for a pilot single-centre, parallel-arm, randomised controlled trial of dietary inulin to improve gut health in solid organ transplantation: the DIGEST study
por: Singer, Julian, et al.
Publicado: (2021)

Impact of HDAC Inhibitors on Protein Quality Control Systems: Consequences for Precision Medicine in Malignant Disease
por: Kulka, Linda Anna Michelle, et al.
Publicado: (2020)

HDAC6 Interacts With Poly (GA) and Modulates its Accumulation in c9FTD/ALS
por: del Rosso, Giulia, et al.
Publicado: (2022)

Peroxisomal Metabolite and Cofactor Transport in Humans
por: Chornyi, Serhii, et al.
Publicado: (2021)

Maintenance of HDACs and H3K9me3 Prevents Arterial Flow-Induced Venous Endothelial Damage
por: Wang, Ting-Yun, et al.
Publicado: (2021)

Short-Chain Fatty Acid Butyrate Induces Cilia Formation and Potentiates the Effects of HDAC6 Inhibitors in Cholangiocarcinoma Cells
por: Pant, Kishor, et al.
Publicado: (2022)

RASSF1A Regulates Spindle Organization by Modulating Tubulin Acetylation via SIRT2 and HDAC6 in Mouse Oocytes
por: Jeon, Hyuk-Joon, et al.
Publicado: (2020)

Timing Does Matter: Nerve-Mediated HDAC1 Paces the Temporal Expression of Morphogenic Genes During Axolotl Limb Regeneration
por: Wang, Mu-Hui, et al.
Publicado: (2021)

Hdac6 regulates Tip60-p400 function in stem cells
por: Chen, Poshen B, et al.
Publicado: (2013)

Promoter Hypomethylation and miR-145-5p Downregulation- Mediated HDAC11 Overexpression Promotes Sorafenib Resistance and Metastasis of Hepatocellular Carcinoma Cells
por: Wang, Wenlong, et al.
Publicado: (2020)

MiR-421 Binds to PINK1 and Enhances Neural Stem Cell Self-Renewal via HDAC3-Dependent FOXO3 Activation
por: Jia, Jiaoying, et al.
Publicado: (2021)

Phosphoinositide Recognition Sites Are Blocked by Metabolite Attachment
por: Kervin, Troy A., et al.
Publicado: (2021)

ER-Phagy and Microbial Infection
por: Li, Jiahui, et al.
Publicado: (2021)

Lymphatic Absorption of Microbial Plasmalogens in Rats
por: Sato, Nana, et al.
Publicado: (2022)

Interleaflet Coupling of Lipid Nanodomains – Insights From in vitro Systems
por: Sarmento, Maria J., et al.
Publicado: (2020)

Computation of Single-Cell Metabolite Distributions Using Mixture Models
por: Tonn, Mona K., et al.
Publicado: (2020)

Metabolic Networks Influencing Skeletal Muscle Fiber Composition
por: Bourdeau Julien, Isabelle, et al.
Publicado: (2018)

The Brm-HDAC3-Erm repressor complex suppresses dedifferentiation in Drosophila type II neuroblast lineages
por: Koe, Chwee Tat, et al.
Publicado: (2014)

Fallopian tube secreted protein affects ovarian metabolites in high grade serous ovarian cancer
por: Bergsten, Tova M., et al.
Publicado: (2022)

Prediction of Ovarian Cancer-Related Metabolites Based on Graph Neural Network
por: Chen, Jingjing, et al.
Publicado: (2021)

LncRNA NORAD Promotes Vascular Endothelial Cell Injury and Atherosclerosis Through Suppressing VEGF Gene Transcription via Enhancing H3K9 Deacetylation by Recruiting HDAC6
por: Kai, Huihua, et al.
Publicado: (2021)

Neurovascular Coupling in Development and Disease: Focus on Astrocytes
por: Stackhouse, Teresa L., et al.
Publicado: (2021)

Targeting the Urotensin II/UT G Protein-Coupled Receptor to Counteract Angiogenesis and Mesenchymal Hypoxia/Necrosis in Glioblastoma
por: Le Joncour, Vadim, et al.
Publicado: (2021)

EED orchestration of heart maturation through interaction with HDACs is H3K27me3-independent
por: Ai, Shanshan, et al.
Publicado: (2017)

Molecular Immune Mechanism of Intestinal Microbiota and Their Metabolites in the Occurrence and Development of Liver Cancer
por: Bi, Chenchen, et al.
Publicado: (2021)

Coupling Phase Behavior of Fatty Acid Containing Membranes to Membrane Bio-Mechanics
por: Tyler, Arwen I. I., et al.
Publicado: (2019)

Extracellular Vesicle-Derived microRNA-410 From Mesenchymal Stem Cells Protects Against Neonatal Hypoxia-Ischemia Brain Damage Through an HDAC1-Dependent EGR2/Bcl2 Axis
por: Han, Jun, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_do9n0kkg0mpuu0mpmfipio9pa7