Advances in Cancer Treatment by Targeting the Neddylation Pathway

Developmental down-regulation protein 8 (NEDD8), expressed by neural progenitors, is a ubiquitin-like protein that conjugates to and regulates the biological function of its substrates. The main target of NEDD8 is cullin-RING E3 ligases. Upregulation of the neddylation pathway is closely associated...

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Autores principales: Gai, Wenbin, Peng, Zhiqiang, Liu, Cui Hua, Zhang, Lingqiang, Jiang, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8060460/
https://www.ncbi.nlm.nih.gov/pubmed/33898451
http://dx.doi.org/10.3389/fcell.2021.653882
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author Gai, Wenbin
Peng, Zhiqiang
Liu, Cui Hua
Zhang, Lingqiang
Jiang, Hong
author_facet Gai, Wenbin
Peng, Zhiqiang
Liu, Cui Hua
Zhang, Lingqiang
Jiang, Hong
author_sort Gai, Wenbin
collection PubMed
description Developmental down-regulation protein 8 (NEDD8), expressed by neural progenitors, is a ubiquitin-like protein that conjugates to and regulates the biological function of its substrates. The main target of NEDD8 is cullin-RING E3 ligases. Upregulation of the neddylation pathway is closely associated with the progression of various tumors, and MLN4924, which inhibits NEDD8-activating enzyme (NAE), is a promising new antitumor compound for combination therapy. Here, we summarize the latest progress in anticancer strategies targeting the neddylation pathway and their combined applications, providing a theoretical reference for developing antitumor drugs and combination therapies.
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spelling pubmed-80604602021-04-23 Advances in Cancer Treatment by Targeting the Neddylation Pathway Gai, Wenbin Peng, Zhiqiang Liu, Cui Hua Zhang, Lingqiang Jiang, Hong Front Cell Dev Biol Cell and Developmental Biology Developmental down-regulation protein 8 (NEDD8), expressed by neural progenitors, is a ubiquitin-like protein that conjugates to and regulates the biological function of its substrates. The main target of NEDD8 is cullin-RING E3 ligases. Upregulation of the neddylation pathway is closely associated with the progression of various tumors, and MLN4924, which inhibits NEDD8-activating enzyme (NAE), is a promising new antitumor compound for combination therapy. Here, we summarize the latest progress in anticancer strategies targeting the neddylation pathway and their combined applications, providing a theoretical reference for developing antitumor drugs and combination therapies. Frontiers Media S.A. 2021-04-08 /pmc/articles/PMC8060460/ /pubmed/33898451 http://dx.doi.org/10.3389/fcell.2021.653882 Text en Copyright © 2021 Gai, Peng, Liu, Zhang and Jiang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Gai, Wenbin
Peng, Zhiqiang
Liu, Cui Hua
Zhang, Lingqiang
Jiang, Hong
Advances in Cancer Treatment by Targeting the Neddylation Pathway
title Advances in Cancer Treatment by Targeting the Neddylation Pathway
title_full Advances in Cancer Treatment by Targeting the Neddylation Pathway
title_fullStr Advances in Cancer Treatment by Targeting the Neddylation Pathway
title_full_unstemmed Advances in Cancer Treatment by Targeting the Neddylation Pathway
title_short Advances in Cancer Treatment by Targeting the Neddylation Pathway
title_sort advances in cancer treatment by targeting the neddylation pathway
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8060460/
https://www.ncbi.nlm.nih.gov/pubmed/33898451
http://dx.doi.org/10.3389/fcell.2021.653882
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