Association of Age, Antipsychotic Medication, and Symptom Severity in Schizophrenia With Proton Magnetic Resonance Spectroscopy Brain Glutamate Level: A Mega-analysis of Individual Participant-Level Data

IMPORTANCE: Proton magnetic resonance spectroscopy (1H-MRS) studies indicate that altered brain glutamatergic function may be associated with the pathophysiology of schizophrenia and the response to antipsychotic treatment. However, the association of altered glutamatergic function with clinical and...

Descripción completa

Detalles Bibliográficos
Autores principales: Merritt, Kate, McGuire, Philip K., Egerton, Alice, Aleman, André, Block, Wolfgang, Bloemen, Oswald J. N., Borgan, Faith, Bustillo, Juan R., Capizzano, Aristides A., Coughlin, Jennifer Marie, De la Fuente-Sandoval, Camilo, Demjaha, Arsime, Dempster, Kara, Do, Kim Q., Du, Fei, Falkai, Peter, Galinska-Skok, Beata, Gallinat, Jurgen, Gasparovic, Charles, Ginestet, Cedric E., Goto, Naoki, Graff-Guerrero, Ariel, Ho, Beng Choon, Howes, Oliver D., Jauhar, Sameer, Jeon, Peter, Kato, Tadafumi, Kaufmann, Charles A., Kegeles, Lawrence S., Keshavan, Matcheri, Kim, Sang-Young, Kunugi, Hiroshi, Lauriello, John, Liemburg, Edith Jantine, Mcilwain, Meghan E., Modinos, Gemma, Mouchlianitis, Elias D., Nakamura, Jun, Nenadic, Igor, Öngür, Dost, Ota, Miho, Palaniyappan, Lena, Pantelis, Christos, Plitman, Eric, Posporelis, Sotirios, Purdon, Scot E., Reichenbach, Jürgen R., Renshaw, Perry F., Russell, Bruce R., Sawa, Akira, Schaefer, Martin, Shungu, Dikoma C., Smesny, Stefan, Stanley, Jeffrey A., Stone, James M., Szulc, Agata, Taylor, Reggie, Thakkar, Katy, Théberge, Jean, Tibbo, Philip G., van Amelsvoort, Therese, Walecki, Jerzy, Williamson, Peter C., Wood, Stephen James, Xin, Lijing, Yamasue, Hidenori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Medical Association 2021
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8060889/
https://www.ncbi.nlm.nih.gov/pubmed/33881460
http://dx.doi.org/10.1001/jamapsychiatry.2021.0380

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8060889/
https://www.ncbi.nlm.nih.gov/pubmed/33881460
http://dx.doi.org/10.1001/jamapsychiatry.2021.0380

Ejemplares similares