Biochemical reconstitution and genetic characterization of the major oxidative damage base excision DNA repair pathway in Thermococcus kodakarensis

Reactive oxygen species drive the oxidation of guanine to 8-oxoguanine (8oxoG), which threatens genome integrity. The repair of 8oxoG is carried out by base excision repair enzymes in Bacteria and Eukarya, however, little is known about archaeal 8oxoG repair. This study identifies a member of the Og...

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Detalles Bibliográficos
Autores principales: Gehring, Alexandra M., Zatopek, Kelly M., Burkhart, Brett W., Potapov, Vladimir, Santangelo, Thomas J., Gardner, Andrew F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8061334/
https://www.ncbi.nlm.nih.gov/pubmed/31841800
http://dx.doi.org/10.1016/j.dnarep.2019.102767

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8061334/
https://www.ncbi.nlm.nih.gov/pubmed/31841800
http://dx.doi.org/10.1016/j.dnarep.2019.102767

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