Cargando…

Multi‐compartment metabolomics and metagenomics reveal major hepatic and intestinal disturbances in cancer cachectic mice

BACKGROUND: Cancer cachexia is a multifactorial syndrome characterized by multiple metabolic dysfunctions. Besides the muscle, other organs such as the liver and the gut microbiota may also contribute to this syndrome. Indeed, the gut microbiota, an important regulator of the host metabolism, is alt...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pötgens, Sarah A., Thibaut, Morgane M., Joudiou, Nicolas, Sboarina, Martina, Neyrinck, Audrey M., Cani, Patrice D., Claus, Sandrine P., Delzenne, Nathalie M., Bindels, Laure B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8061360/ https://www.ncbi.nlm.nih.gov/pubmed/33599103 http://dx.doi.org/10.1002/jcsm.12684

Ejemplares similares

Klebsiella oxytoca expands in cancer cachexia and acts as a gut pathobiont contributing to intestinal dysfunction
por: Pötgens, Sarah A., et al.
Publicado: (2018)

The Janus Face of Cereals: Wheat‐Derived Prebiotics Counteract the Detrimental Effect of Gluten on Metabolic Homeostasis in Mice Fed a High‐Fat/High‐Sucrose Diet
por: Olivares, Marta, et al.
Publicado: (2019)

The DPP-4 inhibitor vildagliptin impacts the gut microbiota and prevents disruption of intestinal homeostasis induced by a Western diet in mice
por: Olivares, Marta, et al.
Publicado: (2018)

Inflammation‐induced cholestasis in cancer cachexia
por: Thibaut, Morgane M., et al.
Publicado: (2020)

Prebiotic Effect of Berberine and Curcumin Is Associated with the Improvement of Obesity in Mice
por: Neyrinck, Audrey M., et al.
Publicado: (2021)

Ffar2 expression regulates leukaemic cell growth in vivo
por: Bindels, Laure B, et al.
Publicado: (2017)

Spirulina Protects against Hepatic Inflammation in Aging: An Effect Related to the Modulation of the Gut Microbiota?
por: Neyrinck, Audrey M., et al.
Publicado: (2017)

Wheat-derived arabinoxylan oligosaccharides with bifidogenic properties abolishes metabolic disorders induced by western diet in mice
por: Neyrinck, Audrey M., et al.
Publicado: (2018)

Breath volatile metabolome reveals the impact of dietary fibres on the gut microbiota: Proof of concept in healthy volunteers
por: Neyrinck, Audrey M., et al.
Publicado: (2022)

Synbiotic approach restores intestinal homeostasis and prolongs survival in leukaemic mice with cachexia
por: Bindels, Laure B, et al.
Publicado: (2016)

Intestinal Sucrase as a Novel Target Contributing to the Regulation of Glycemia by Prebiotics
por: Neyrinck, Audrey M., et al.
Publicado: (2016)

Chitin–glucan and pomegranate polyphenols improve endothelial dysfunction
por: Neyrinck, Audrey M., et al.
Publicado: (2019)

Constipation Mitigation by Rhubarb Extract in Middle-Aged Adults Is Linked to Gut Microbiome Modulation: A Double-Blind Randomized Placebo-Controlled Trial
por: Neyrinck, Audrey M., et al.
Publicado: (2022)

Modulation of the gut microbiota by nutrients with prebiotic properties: consequences for host health in the context of obesity and metabolic syndrome
por: Delzenne, Nathalie M, et al.
Publicado: (2011)

Fat binding capacity and modulation of the gut microbiota both determine the effect of wheat bran fractions on adiposity
por: Suriano, Francesco, et al.
Publicado: (2017)

Implication of trans-11,trans-13 conjugated linoleic acid in the development of hepatic steatosis
por: Pachikian, Barbara D., et al.
Publicado: (2018)

Inulin Improves Postprandial Hypertriglyceridemia by Modulating Gene Expression in the Small Intestine
por: Hiel, Sophie, et al.
Publicado: (2018)

Insight into the prebiotic concept: lessons from an exploratory, double blind intervention study with inulin-type fructans in obese women
por: Dewulf, Evelyne M, et al.
Publicado: (2013)

Functional Effects of EPS-Producing Bifidobacterium Administration on Energy Metabolic Alterations of Diet-Induced Obese Mice
por: Salazar, Nuria, et al.
Publicado: (2019)

Improvement of gastrointestinal discomfort and inflammatory status by a synbiotic in middle-aged adults: a double-blind randomized placebo-controlled trial
por: Neyrinck, Audrey M., et al.
Publicado: (2021)

Publisher Correction: Microbiota analysis and transient elastography reveal new extra-hepatic components of liver steatosis and fibrosis in obese patients
por: Lanthier, Nicolas, et al.
Publicado: (2021)

Microbiota analysis and transient elastography reveal new extra-hepatic components of liver steatosis and fibrosis in obese patients
por: Lanthier, Nicolas, et al.
Publicado: (2021)

Discovery of the gut microbial signature driving the efficacy of prebiotic intervention in obese patients
por: Rodriguez, Julie, et al.
Publicado: (2020)

Hepatoprotective Effects of Indole, a Gut Microbial Metabolite, in Leptin-Deficient Obese Mice
por: Knudsen, Christelle, et al.
Publicado: (2021)

A dynamic association between myosteatosis and liver stiffness: Results from a prospective interventional study in obese patients
por: Nachit, Maxime, et al.
Publicado: (2021)

Role of the Lower and Upper Intestine in the Production and Absorption of Gut Microbiota-Derived PUFA Metabolites
por: Druart, Céline, et al.
Publicado: (2014)

Impairment of aryl hydrocarbon receptor signalling promotes hepatic disorders in cancer cachexia
por: Dolly, Adeline, et al.
Publicado: (2023)

The gut microbiota metabolite indole alleviates liver inflammation in mice
por: Beaumont, Martin, et al.
Publicado: (2018)

A Preventive Prebiotic Supplementation Improves the Sweet Taste Perception in Diet-Induced Obese Mice
por: Bernard, Arnaud, et al.
Publicado: (2019)

Prebiotics supplementation improves the endothelial dysfunction in n-3 PUFA-depleted ApoE(-/-) mice
por: Catry, Emilie, et al.
Publicado: (2014)

Physical activity enhances the improvement of body mass index and metabolism by inulin: a multicenter randomized placebo-controlled trial performed in obese individuals
por: Rodriguez, Julie, et al.
Publicado: (2022)

Multiplatform Urinary Metabolomics Profiling to Discriminate Cachectic from Non-Cachectic Colorectal Cancer Patients: Pilot Results from the ColoCare Study
por: Ose, Jennifer, et al.
Publicado: (2019)

Noninvasive monitoring of fibre fermentation in healthy volunteers by analyzing breath volatile metabolites: lessons from the FiberTAG intervention study
por: Neyrinck, Audrey M., et al.
Publicado: (2021)

Curcuma longa Extract Associated with White Pepper Lessens High Fat Diet-Induced Inflammation in Subcutaneous Adipose Tissue
por: Neyrinck, Audrey M., et al.
Publicado: (2013)

Increased gut permeability in cancer cachexia: mechanisms and clinical relevance
por: Bindels, Laure B., et al.
Publicado: (2018)

Evaluation of the relationship between GPR43 and adiposity in human
por: Dewulf, Evelyne M, et al.
Publicado: (2013)

Non Digestible Oligosaccharides Modulate the Gut Microbiota to Control the Development of Leukemia and Associated Cachexia in Mice
por: Bindels, Laure B., et al.
Publicado: (2015)

Microbiota and Metabolite Profiling as Markers of Mood Disorders: A Cross-Sectional Study in Obese Patients
por: Leyrolle, Quentin, et al.
Publicado: (2021)

Prebiotic Effects of Wheat Arabinoxylan Related to the Increase in Bifidobacteria, Roseburia and Bacteroides/Prevotella in Diet-Induced Obese Mice
por: Neyrinck, Audrey M., et al.
Publicado: (2011)

Effects of a diet based on inulin-rich vegetables on gut health and nutritional behavior in healthy humans
por: Hiel, Sophie, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_kpo2shmi1aba41tifhv19rl6cg