Camptothecin Inhibits Neddylation to Activate the Protective Autophagy Through NF-κB/AMPK/mTOR/ULK1 Axis in Human Esophageal Cancer Cells

The neddylation pathway is overactivated in esophageal cancer. Our previous studies indicated that inactivation of neddylation by the NAE inhibitor induced apoptosis and autophagy in cancer cells. Camptothecin (CPT), a well-known anticancer agent, could induce apoptosis and autophagy in cancer cells...

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Detalles Bibliográficos
Autores principales: Heng, Yongqing, Liang, Yupei, Zhang, Junqian, Li, Lihui, Zhang, Wenjuan, Jiang, Yanyu, Wang, Shiwen, Jia, Lijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8061413/
https://www.ncbi.nlm.nih.gov/pubmed/33898327
http://dx.doi.org/10.3389/fonc.2021.671180

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8061413/
https://www.ncbi.nlm.nih.gov/pubmed/33898327
http://dx.doi.org/10.3389/fonc.2021.671180

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