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Clinical Significance of Shared T Cell Epitope Analysis in Early De Novo Donor-Specific Anti-HLA Antibody Production After Kidney Transplantation and Comparison With Shared B cell Epitope Analysis

In pre-sensitizing events, immunological memory is mainly created via indirect allorecognition where CD4(+) T cells recognize foreign peptides in the context of self-HLA class II (pHLA) presented on antigen-presenting cells. This recognition makes it possible for naive CD4(+) T-helper cells to diffe...

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Detalles Bibliográficos
Autores principales: Tomosugi, Toshihide, Iwasaki, Kenta, Sakamoto, Shintaro, Niemann, Matthias, Spierings, Eric, Nahara, Isao, Futamura, Kenta, Okada, Manabu, Hiramitsu, Takahisa, Takeda, Asami, Goto, Norihiko, Narumi, Shunji, Watarai, Yoshihiko, Kobayashi, Takaaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8061417/
https://www.ncbi.nlm.nih.gov/pubmed/33897684
http://dx.doi.org/10.3389/fimmu.2021.621138