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Bone Marrow Mesenchymal Stromal Cell-mediated Resistance in Multiple Myeloma Against NK Cells can be Overcome by Introduction of CD38-CAR or TRAIL-variant

We have recently shown the strong negative impact of multiple myeloma (MM)-bone marrow mesenchymal stromal cell (BMMSC) interactions to several immunotherapeutic strategies including conventional T cells, chimeric antigen receptor (CAR) T cells, and daratumumab-redirected NK cells. This BMMSC-mediat...

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Detalles Bibliográficos
Autores principales: Holthof, Lisa C., Stikvoort, Arwen, van der Horst, Hilma J., Gelderloos, Anne T., Poels, Renée, Li, Fengzhi, Groen, Richard W. J., Zweegman, Sonja, van de Donk, Niels W. C. J., O’Dwyer, Michael, Mutis, Tuna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8061681/
https://www.ncbi.nlm.nih.gov/pubmed/33898931
http://dx.doi.org/10.1097/HS9.0000000000000561