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Central administration of sodium-glucose cotransporter-2 inhibitors increases food intake involving adenosine monophosphate-activated protein kinase phosphorylation in the lateral hypothalamus in healthy rats

INTRODUCTION: Sodium glucose cotransporter-2 (SGLT2) inhibitors are widely used for diabetes treatment. Although SGLT2 inhibitors have been clinically observed to increase food intake, roles or even the presence of SGLT2 in the central nervous system (CNS) has not been established. We aimed to eluci...

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Detalles Bibliográficos
Autores principales: Takeda, Kenji, Ono, Hiraku, Ishikawa, Ko, Ohno, Tomohiro, Kumagai, Jin, Ochiai, Hidetoshi, Matumoto, Ai, Yokoh, Hidetaka, Maezawa, Yoshiro, Yokote, Koutaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8061802/
https://www.ncbi.nlm.nih.gov/pubmed/33879516
http://dx.doi.org/10.1136/bmjdrc-2020-002104