Cargando…

Amino acids and RagD potentiate mTORC1 activation in CD8(+) T cells to confer antitumor immunity

BACKGROUND: In the tumor microenvironment, tumor cells are able to suppress antitumor immunity by competing for essential nutrients, including amino acids. However, whether amino acid depletion modulates the activity of CD8(+) tumor-infiltrating lymphocytes (TILs) is unclear. METHOD: In this study,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Yiwen, Hu, Hongrong, Liu, Weiwei, Yan, Shu-Mei, Li, Yuzhuang, Tan, Likai, Chen, Yingshi, Liu, Jun, Peng, Zhilin, Yuan, Yaochang, Huang, Wenjing, Yu, Fei, He, Xin, Li, Bo, Zhang, Hui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2021
Materias:	Basic Tumor Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8061841/ https://www.ncbi.nlm.nih.gov/pubmed/33883257 http://dx.doi.org/10.1136/jitc-2020-002137

Ejemplares similares

Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction
por: Kim, Jong Hyun, et al.
Publicado: (2017)

Regulation of mTORC1 by the Rag GTPases
por: Lama-Sherpa, Tshering D., et al.
Publicado: (2023)

TP53/mTORC1-mediated bidirectional regulation of PD-L1 modulates immune evasion in hepatocellular carcinoma
por: Yu, Jiongjie, et al.
Publicado: (2023)

Mitochondrial reactive oxygen species trigger metformin-dependent antitumor immunity via activation of Nrf2/mTORC1/p62 axis in tumor-infiltrating CD8T lymphocytes
por: Nishida, Mikako, et al.
Publicado: (2021)

RagD auto-activating mutations impair MiT/TFE activity in kidney tubulopathy and cardiomyopathy syndrome
por: Sambri, Irene, et al.
Publicado: (2023)

A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids
por: Gollwitzer, Peter, et al.
Publicado: (2022)

The yoga of Rag GTPases: Dynamic structural poses confer amino acid sensing by mTORC1
por: Fingar, Diane C.
Publicado: (2021)

Structure of the lysosomal mTORC1–TFEB–Rag–Ragulator megacomplex
por: Cui, Zhicheng, et al.
Publicado: (2023)

An interdomain hydrogen bond in the Rag GTPases maintains stable mTORC1 signaling in sensing amino acids
por: Egri, Shawn B., et al.
Publicado: (2021)

Author Correction: A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids
por: Gollwitzer, Peter, et al.
Publicado: (2022)

Regulation of adiposity by mTORC1
por: Magdalon, Juliana, et al.
Publicado: (2017)

Src regulates amino acid-mediated mTORC1 activation by disrupting GATOR1-Rag GTPase interaction
por: Pal, Rituraj, et al.
Publicado: (2018)

Modulation of lactate-lysosome axis in dendritic cells by clotrimazole potentiates antitumor immunity
por: Wang, Zining, et al.
Publicado: (2021)

Mutations of RagA GTPase in mTORC1 Pathway Are Associated with Autosomal Dominant Cataracts
por: Chen, Jian-Huan, et al.
Publicado: (2016)

mTORC2 Steals the Spotlight
por: Jansen, Laura A.
Publicado: (2020)

Chlorpromazine affects autophagy in association with altered Rag GTPase–mTORC1–TFEB signaling
por: Li, Ningning, et al.
Publicado: (2023)

Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1
por: Zhang, Tianlong, et al.
Publicado: (2017)

Blockades of effector T cell senescence and exhaustion synergistically enhance antitumor immunity and immunotherapy
por: Liu, Xia, et al.
Publicado: (2022)

Single-cell sequencing reveals antitumor characteristics of intratumoral immune cells in old mice
por: Zhang, Cangang, et al.
Publicado: (2021)

An mTORC1-mediated negative feedback loop constrains amino acid-induced FLCN-Rag activation in renal cells with TSC2 loss
por: Asrani, Kaushal, et al.
Publicado: (2022)

Antagonistic anti-LILRB1 monoclonal antibody regulates antitumor functions of natural killer cells
por: Chen, Heyu, et al.
Publicado: (2020)

MDSCs-derived GPR84 induces CD8(+) T-cell senescence via p53 activation to suppress the antitumor response
por: Liu, Jinyan, et al.
Publicado: (2023)

Rictor/mTORC2 signaling mediates TGFβ1-induced fibroblast activation and kidney fibrosis
por: Li, Jianzhong, et al.
Publicado: (2015)

Combining IL-2-based immunotherapy with commensal probiotics produces enhanced antitumor immune response and tumor clearance
por: Shi, Linlin, et al.
Publicado: (2020)

Restoration of miR-340 controls pancreatic cancer cell CD47 expression to promote macrophage phagocytosis and enhance antitumor immunity
por: Xi, Qing, et al.
Publicado: (2020)

Amino acid metabolites, mTORC1 and aging
por: Antikainen, Henri, et al.
Publicado: (2017)

The lysosomal GPCR-like protein GPR137B regulates Rag and mTORC1 localization and activity
por: Gan, Lin, et al.
Publicado: (2019)

HIV-1 enhances mTORC1 activity and repositions lysosomes to the periphery by co-opting Rag GTPases
por: Cinti, Alessandro, et al.
Publicado: (2017)

Folliculin promotes substrate-selective mTORC1 activity by activating RagC to recruit TFE3
por: Li, Kristina, et al.
Publicado: (2022)

IL-31 induces antitumor immunity in breast carcinoma
por: Kan, Tal, et al.
Publicado: (2020)

TFAM deficiency in dendritic cells leads to mitochondrial dysfunction and enhanced antitumor immunity through cGAS-STING pathway
por: Lu, Tianqi, et al.
Publicado: (2023)

BRCA1 deficiency in mature CD8(+) T lymphocytes impairs antitumor immunity
por: Wu, Bogang, et al.
Publicado: (2023)

LRIG2 promotes glioblastoma progression by modulating innate antitumor immunity through macrophage infiltration and polarization
por: Hu, Jinyang, et al.
Publicado: (2022)

Enhanced antitumor immunity by a novel small molecule HPK1 inhibitor
por: You, Dan, et al.
Publicado: (2021)

Switch receptor T3/28 improves long-term persistence and antitumor efficacy of CAR-T cells
por: Zhao, Songbo, et al.
Publicado: (2021)

Tumorous expression of NAC1 restrains antitumor immunity through the LDHA-mediated immune evasion
por: Ren, Yijie, et al.
Publicado: (2022)

Vaccination with early ferroptotic cancer cells induces efficient antitumor immunity
por: Efimova, Iuliia, et al.
Publicado: (2020)

CXCR6 is required for antitumor efficacy of intratumoral CD8(+) T cell
por: Wang, Binglin, et al.
Publicado: (2021)

Activation of GM-CSF and TLR2 signaling synergistically enhances antigen-specific antitumor immunity and modulates the tumor microenvironment
por: Yan, Wan-Lun, et al.
Publicado: (2021)

Loss of YTHDF1 in gastric tumors restores sensitivity to antitumor immunity by recruiting mature dendritic cells
por: Bai, Xiaowu, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_k2lupr2hmrlj23jem857pmofal