Amino acids and RagD potentiate mTORC1 activation in CD8(+) T cells to confer antitumor immunity

BACKGROUND: In the tumor microenvironment, tumor cells are able to suppress antitumor immunity by competing for essential nutrients, including amino acids. However, whether amino acid depletion modulates the activity of CD8(+) tumor-infiltrating lymphocytes (TILs) is unclear. METHOD: In this study,...

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Detalles Bibliográficos
Autores principales: Zhang, Yiwen, Hu, Hongrong, Liu, Weiwei, Yan, Shu-Mei, Li, Yuzhuang, Tan, Likai, Chen, Yingshi, Liu, Jun, Peng, Zhilin, Yuan, Yaochang, Huang, Wenjing, Yu, Fei, He, Xin, Li, Bo, Zhang, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8061841/
https://www.ncbi.nlm.nih.gov/pubmed/33883257
http://dx.doi.org/10.1136/jitc-2020-002137

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8061841/
https://www.ncbi.nlm.nih.gov/pubmed/33883257
http://dx.doi.org/10.1136/jitc-2020-002137

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