Mitochondrial reactive oxygen species trigger metformin-dependent antitumor immunity via activation of Nrf2/mTORC1/p62 axis in tumor-infiltrating CD8T lymphocytes

BACKGROUND: Metformin (Met) is the first-line treatment for type 2 diabetes mellitus and plays an effective role in treating various diseases, such as cardiovascular disease, neurodegenerative disease, cancer, and aging. However, the underlying mechanism of Met-dependent antitumor immunity remains t...

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Detalles Bibliográficos
Autores principales: Nishida, Mikako, Yamashita, Nahoko, Ogawa, Taisaku, Koseki, Keita, Warabi, Eiji, Ohue, Tomoyuki, Komatsu, Masaaki, Matsushita, Hirokazu, Kakimi, Kazuhiro, Kawakami, Eiryo, Shiroguchi, Katsuyuki, Udono, Heiichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8449974/
https://www.ncbi.nlm.nih.gov/pubmed/34531248
http://dx.doi.org/10.1136/jitc-2021-002954

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8449974/
https://www.ncbi.nlm.nih.gov/pubmed/34531248
http://dx.doi.org/10.1136/jitc-2021-002954

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