Larazotide acetate induces recovery of ischemia-injured porcine jejunum via repair of tight junctions

Intestinal ischemia results in mucosal injury, including paracellular barrier loss due to disruption of tight junctions. Larazotide acetate (LA), a small peptide studied in Phase III clinical trials for treatment of celiac disease, regulates tight junctions (TJs). We hypothesized that LA would dose-...

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Detalles Bibliográficos
Autores principales: Slifer, Zachary M., Hernandez, Liliana, Pridgen, Tiffany A., Carlson, Alexandra R., Messenger, Kristen M., Madan, Jay, Krishnan, B. Radha, Laumas, Sandeep, Blikslager, Anthony T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8061941/
https://www.ncbi.nlm.nih.gov/pubmed/33886649
http://dx.doi.org/10.1371/journal.pone.0250165

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8061941/
https://www.ncbi.nlm.nih.gov/pubmed/33886649
http://dx.doi.org/10.1371/journal.pone.0250165

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