High-throughput screening of the ReFRAME, Pandemic Box, and COVID Box drug repurposing libraries against SARS-CoV-2 nsp15 endoribonuclease to identify small-molecule inhibitors of viral activity

SARS-CoV-2 has caused a global pandemic, and has taken over 1.7 million lives as of mid-December, 2020. Although great progress has been made in the development of effective countermeasures, with several pharmaceutical companies approved or poised to deliver vaccines to market, there is still an unm...

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Detalles Bibliográficos
Autores principales: Choi, Ryan, Zhou, Mowei, Shek, Roger, Wilson, Jesse W., Tillery, Logan, Craig, Justin K., Salukhe, Indraneel A., Hickson, Sarah E., Kumar, Neeraj, James, Rhema M., Buchko, Garry W., Wu, Ruilian, Huff, Sydney, Nguyen, Tu-Trinh, Hurst, Brett L., Cherry, Sara, Barrett, Lynn K., Hyde, Jennifer L., Van Voorhis, Wesley C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062000/
https://www.ncbi.nlm.nih.gov/pubmed/33886614
http://dx.doi.org/10.1371/journal.pone.0250019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062000/
https://www.ncbi.nlm.nih.gov/pubmed/33886614
http://dx.doi.org/10.1371/journal.pone.0250019

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