Cargando…

Octreotide inhibits secretion of IGF-1 from orbital fibroblasts in patients with thyroid-associated ophthalmopathy via inhibition of the NF-κB pathway

PURPOSE: We investigated the effect of octreotide, a long-acting somatostatin (SST) analogue, on IGF-1 secretion and its possible mechanism of action in orbital fibroblasts (OFs) from patients with thyroid-associated ophthalmopathy (TAO). MATERIALS AND METHODS: OFs were isolated from the orbital fat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Sung Eun, Kim, Jia, Lee, Ji-Young, Lee, Seong-Beom, Paik, Ji-Sun, Yang, Suk-Woo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062018/ https://www.ncbi.nlm.nih.gov/pubmed/33886620 http://dx.doi.org/10.1371/journal.pone.0249988

Ejemplares similares

Palmitate induced secretion of IL-6 and MCP-1 in orbital fibroblasts derived from patients with thyroid-associated ophthalmopathy
por: Paik, Ji-Sun, et al.
Publicado: (2012)

The Effect of (-)-Epigallocatechin-3-Gallate on IL-1β Induced IL-8 Expression in Orbital Fibroblast from Patients with Thyroid-Associated Ophthalmopathy
por: Lee, Ji-Young, et al.
Publicado: (2016)

Chitosan inhibits inflammation and adipogenesis of orbital fibroblasts in Graves ophthalmopathy
por: Xiong, Haibo, et al.
Publicado: (2018)

Effect of Orbital Decompression on Corneal Topography in Patients with Thyroid Ophthalmopathy
por: Kim, Su Ah, et al.
Publicado: (2015)

Functionally enhanced placenta-derived mesenchymal stem cells inhibit adipogenesis in orbital fibroblasts with Graves’ ophthalmopathy
por: Kim, Jae Yeon, et al.
Publicado: (2020)

Increased response to oxidative stress challenge in Graves’ ophthalmopathy orbital fibroblasts
por: Tsai, Chieh-Chih, et al.
Publicado: (2011)

Benzylideneacetophenone derivatives attenuate IFN-γ-induced IP-10/CXCL10 production in orbital fibroblasts of patients with thyroid-associated ophthalmopathy through STAT-1 inhibition
por: Lee, Sung-Hee, et al.
Publicado: (2014)

Simvastatin Inhibits CYR61 Expression in Orbital Fibroblasts in Graves' Ophthalmopathy through the Regulation of FoxO3a Signaling
por: Wei, Yi-Hsuan, et al.
Publicado: (2021)

Integrative Analysis of Proteomics and DNA Methylation in Orbital Fibroblasts From Graves’ Ophthalmopathy
por: Virakul, Sita, et al.
Publicado: (2021)

The protective effect of antioxidants on orbital fibroblasts from patients with Graves’ ophthalmopathy in response to oxidative stress
por: Tsai, Chieh-Chih, et al.
Publicado: (2013)

Imaging Evaluation of the Orbit in Graves Ophthalmopathy
por: SAS, T.N., et al.
Publicado: (2015)

Orbital endoscopic decompression in Graves Ophthalmopathy
por: Lima, Wilma Terezinha Anselmo, et al.
Publicado: (2015)

MiRNA-21 promotes fibrosis in orbital fibroblasts from thyroid-associated ophthalmopathy
por: Bo-ding, Tong, et al.
Publicado: (2015)

Dihydroartemisinin Exerts Antifibrotic and Anti-Inflammatory Effects in Graves’ Ophthalmopathy by Targeting Orbital Fibroblasts
por: Yang, Shenglan, et al.
Publicado: (2022)

Octreotide s.c. depot provides sustained octreotide bioavailability and similar IGF-1 suppression to octreotide LAR in healthy volunteers
por: Tiberg, Fredrik, et al.
Publicado: (2015)

A cyclic vertical deviation with dysthyroid ophthalmopathy: a case report
por: Paik, Ji-Sun, et al.
Publicado: (2016)

Gypenosides Protect Orbital Fibroblasts in Graves Ophthalmopathy via Anti-Inflammation and Anti-Fibrosis Effects
por: Li, Haoyu, et al.
Publicado: (2020)

IL-11 Is Elevated and Drives the Profibrotic Phenotype Transition of Orbital Fibroblasts in Thyroid-Associated Ophthalmopathy
por: Wu, Pengsen, et al.
Publicado: (2022)

Octreotide Protects the Mouse Retina against Ischemic Reperfusion Injury through Regulation of Antioxidation and Activation of NF-κB
por: Wang, Jun, et al.
Publicado: (2015)

Inhibitory Effects of α-Lipoic Acid on Oxidative Stress-Induced Adipogenesis in Orbital Fibroblasts From Patients With Graves Ophthalmopathy
por: Hwang, Sena, et al.
Publicado: (2016)

Alteration of Connective Tissue Growth Factor (CTGF) Expression in Orbital Fibroblasts from Patients with Graves’ Ophthalmopathy
por: Tsai, Chieh-Chih, et al.
Publicado: (2015)

Potential Therapeutic Activity of Berberine in Thyroid-Associated Ophthalmopathy: Inhibitory Effects on Tissue Remodeling in Orbital Fibroblasts
por: Diao, Jiale, et al.
Publicado: (2022)

The outcomes of endoscopic orbital decompression combined with fat decompression for thyroid-associated ophthalmopathy
por: Ye, Yunyan, et al.
Publicado: (2023)

Adiponectin concentration in the orbital fat of patients with Graves’ ophthalmopathy
por: Soiberman, Uri, et al.
Publicado: (2013)

MicroRNA-146a downregulates the production of hyaluronic acid and collagen I in Graves' ophthalmopathy orbital fibroblasts
por: Liu, Wei, et al.
Publicado: (2020)

Simvastatin downregulates adipogenesis in 3T3-L1 preadipocytes and orbital fibroblasts from Graves’ ophthalmopathy patients
por: Shahida, B, et al.
Publicado: (2019)

Graves’ ophthalmopathy: low-dose dexamethasone reduces retinoic acid receptor-alpha gene expression in orbital fibroblasts
por: Cury, Sarah Santiloni, et al.
Publicado: (2018)

CD34(−) Orbital Fibroblasts From Patients With Thyroid-Associated Ophthalmopathy Modulate TNF-α Expression in CD34(+) Fibroblasts and Fibrocytes
por: Lu, Yan, et al.
Publicado: (2018)

The Change of Lacrimal Gland Volume in Korean Patients with Thyroid-associated Ophthalmopathy
por: Huh, Hyoun-Do, et al.
Publicado: (2016)

Natural Sulfurs Inhibit LPS-Induced Inflammatory Responses through NF-κB Signaling in CCD-986Sk Skin Fibroblasts
por: Sp, Nipin, et al.
Publicado: (2021)

Simvastatin and ROCK Inhibitor Y-27632 Inhibit Myofibroblast Differentiation of Graves’ Ophthalmopathy-Derived Orbital Fibroblasts via RhoA-Mediated ERK and p38 Signaling Pathways
por: Wei, Yi-Hsuan, et al.
Publicado: (2021)

Isatis tinctoria L. Leaf Extract Inhibits Replicative Senescence in Dermal Fibroblasts by Regulating mTOR-NF-κB-SASP Signaling
por: Woo, Jieun, et al.
Publicado: (2022)

Comparative assessment of Graves’ disease and main extrathyroidal manifestation, Graves’ ophthalmopathy, by non-targeted metabolite profiling of blood and orbital tissue
por: Ji, Dong Yoon, et al.
Publicado: (2018)

A Case of Orbital Abscess following Porous Orbital Implant Infection
por: Hong, Seung Woo, et al.
Publicado: (2006)

The Type III Secretion Effector NleE Inhibits NF-κB Activation
por: Nadler, Chen, et al.
Publicado: (2010)

PD-L1 Inhibits T Cell-Induced Cytokines and Hyaluronan Expression via the CD40-CD40L Pathway in Orbital Fibroblasts From Patients With Thyroid Associated Ophthalmopathy
por: Liu, Zhibin, et al.
Publicado: (2022)

Lessons Learned from Targeting IGF-I Receptor in Thyroid-Associated Ophthalmopathy
por: Janssen, Joseph A.M.J.L., et al.
Publicado: (2021)

Cigarette Smoke Extract-Induced Oxidative Stress and Fibrosis-Related Genes Expression in Orbital Fibroblasts from Patients with Graves' Ophthalmopathy
por: Kau, Hui-Chuan, et al.
Publicado: (2016)

Effect of Pirfenidone on TGF-β1-Induced Myofibroblast Differentiation and Extracellular Matrix Homeostasis of Human Orbital Fibroblasts in Graves’ Ophthalmopathy
por: Wu, Shi-Bei, et al.
Publicado: (2021)

Changes in Choroidal Perfusion after Orbital Decompression Surgery for Graves' Ophthalmopathy
por: Nik, Narieman, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_h41sbecdi9rq08i1jh510kbo2p