Quantification of N-terminal amyloid-β isoforms reveals isomers are the most abundant form of the amyloid-β peptide in sporadic Alzheimer’s disease

Plaques that characterize Alzheimer’s disease accumulate over 20 years as a result of decreased clearance of amyloid-β peptides. Such long-lived peptides are subjected to multiple post-translational modifications, in particular isomerization. Using liquid chromatography ion mobility separations mass...

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Detalles Bibliográficos
Autores principales: Mukherjee, Soumya, Perez, Keyla A, Lago, Larissa C, Klatt, Stephan, McLean, Catriona A, Birchall, Ian E, Barnham, Kevin J, Masters, Colin L, Roberts, Blaine R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062259/
https://www.ncbi.nlm.nih.gov/pubmed/33928245
http://dx.doi.org/10.1093/braincomms/fcab028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062259/
https://www.ncbi.nlm.nih.gov/pubmed/33928245
http://dx.doi.org/10.1093/braincomms/fcab028

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