An experimental medicine study of the phosphodiesterase-4 inhibitor, roflumilast, on working memory-related brain activity and episodic memory in schizophrenia patients

RATIONALE: Schizophrenia is associated with impairments in cognitive functioning yet there are no approved drugs to treat these deficits. OBJECTIVES: Based on animal models, we investigated the potential for roflumilast, a selective inhibitor of phosphodiesterase type 4 (PDE4), to improve cognition,...

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Detalles Bibliográficos
Autores principales: Gilleen, James, Farah, Yakub, Davison, Cate, Kerins, Sarah, Valdearenas, Lorena, Uz, Tolga, Lahu, Gez, Tsai, Max, Ogrinc, Frank, Reichenberg, Avi, Williams, Steve C., Mehta, Mitul A., Shergill, Sukhi S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062361/
https://www.ncbi.nlm.nih.gov/pubmed/30536081
http://dx.doi.org/10.1007/s00213-018-5134-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062361/
https://www.ncbi.nlm.nih.gov/pubmed/30536081
http://dx.doi.org/10.1007/s00213-018-5134-y

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