Crystal structures of an E1–E2–ubiquitin thioester mimetic reveal molecular mechanisms of transthioesterification

E1 enzymes function as gatekeepers of ubiquitin (Ub) signaling by catalyzing activation and transfer of Ub to tens of cognate E2 conjugating enzymes in a process called E1–E2 transthioesterification. The molecular mechanisms of transthioesterification and the overall architecture of the E1–E2–Ub com...

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Detalles Bibliográficos
Autores principales: Yuan, Lingmin, Lv, Zongyang, Adams, Melanie J., Olsen, Shaun K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062481/
https://www.ncbi.nlm.nih.gov/pubmed/33888705
http://dx.doi.org/10.1038/s41467-021-22598-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062481/
https://www.ncbi.nlm.nih.gov/pubmed/33888705
http://dx.doi.org/10.1038/s41467-021-22598-y

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