Pharmacological modulation of AMPA receptors rescues specific impairments in social behavior associated with the A350V Iqsec2 mutation

In this study we tested the hypothesis that pharmacological modulation of glutamatergic neurotransmission could rescue behavioral deficits exhibited by mice carrying a specific mutation in the Iqsec2 gene. The IQSEC2 protein plays a key role in glutamatergic synapses and mutations in the IQSEC2 gene...

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Detalles Bibliográficos
Autores principales: Jabarin, Renad, Levy, Nina, Abergel, Yasmin, Berman, Joshua H., Zag, Amir, Netser, Shai, Levy, Andrew P., Wagner, Shlomo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062516/
https://www.ncbi.nlm.nih.gov/pubmed/33888678
http://dx.doi.org/10.1038/s41398-021-01347-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062516/
https://www.ncbi.nlm.nih.gov/pubmed/33888678
http://dx.doi.org/10.1038/s41398-021-01347-1

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