BRCA1 degradation in response to mitochondrial damage in breast cancer cells

BRCA1 is a well-studied tumor suppressor involved in the homologous repair of DNA damage, whereas PINK1, a mitochondrial serine/threonine kinase, is known to be involved in mitochondrial quality control. Genetic mutations of PINK1 and Parkin cause autosomal recessive early-onset Parkinson’s disease....

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Detalles Bibliográficos
Autores principales: Miyahara, Kana, Takano, Naoharu, Yamada, Yumiko, Kazama, Hiromi, Tokuhisa, Mayumi, Hino, Hirotsugu, Fujita, Koji, Barroga, Edward, Hiramoto, Masaki, Handa, Hiroshi, Kuroda, Masahiko, Ishikawa, Takashi, Miyazawa, Keisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062582/
https://www.ncbi.nlm.nih.gov/pubmed/33888730
http://dx.doi.org/10.1038/s41598-021-87698-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062582/
https://www.ncbi.nlm.nih.gov/pubmed/33888730
http://dx.doi.org/10.1038/s41598-021-87698-7

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