Cargando…

MR1-Restricted MAIT Cells From The Human Lung Mucosal Surface Have Distinct Phenotypic, Functional, and Transcriptomic Features That Are Preserved in HIV Infection

Mucosal associated invariant T (MAIT) cells are a class of innate-like T cells that utilize a semi-invariant αβ T cell receptor to recognize small molecule ligands produced by bacteria and fungi. Despite growing evidence that immune cells at mucosal surfaces are often phenotypically and functionally...

Descripción completa

Detalles Bibliográficos
Autores principales:	Khuzwayo, Sharon, Mthembu, Maphe, Meermeier, Erin W., Prakadan, Sanjay M., Kazer, Samuel W., Bassett, Thierry, Nyamande, Kennedy, Khan, Dilshaad Fakey, Maharaj, Priya, Mitha, Mohammed, Suleman, Moosa, Mhlane, Zoey, Ramjit, Dirhona, Karim, Farina, Shalek, Alex K., Lewinsohn, David M., Ndung’u, Thumbi, Wong, Emily B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062704/ https://www.ncbi.nlm.nih.gov/pubmed/33897687 http://dx.doi.org/10.3389/fimmu.2021.631410

Ejemplares similares

Contrasting Inflammatory Signatures in Peripheral Blood and Bronchoalveolar Cells Reveal Compartment-Specific Effects of HIV Infection
por: Muema, Daniel M., et al.
Publicado: (2020)

Discrepancy between Mtb-specific IFN-γ and IgG responses in HIV-positive people with low CD4 counts
por: Mthembu, Maphe, et al.
Publicado: (2023)

Multiple microbiologic tests for tuberculosis improve diagnostic yield of bronchoscopy in medically complex patients
por: Fakey Khan, Dilshaad, et al.
Publicado: (2019)

TRAV1-2(+) CD8(+) T-cells including oligoconal expansions of MAIT cells are enriched in the airways in human tuberculosis
por: Wong, Emily B., et al.
Publicado: (2019)

High sensitivity of ultrasound for the diagnosis of tuberculosis in adults in South Africa: A proof-of-concept study
por: Fentress, Matthew, et al.
Publicado: (2022)

A PowerPack of SuperScientists: An innovative concept by African scientists to address gender bias and inequity in science
por: Mthembu, Maphe, et al.
Publicado: (2023)

Low Levels of Peripheral CD161++CD8+ Mucosal Associated Invariant T (MAIT) Cells Are Found in HIV and HIV/TB Co-Infection
por: Wong, Emily B., et al.
Publicado: (2013)

People living with HIV and COVID-19: A report on 2 clinical cases from South Africa
por: Mitha, M, et al.
Publicado: (2020)

Alternative splicing of MR1 regulates antigen presentation to MAIT cells
por: Narayanan, Gitanjali A., et al.
Publicado: (2020)

The KT Jeang retrovirology prize 2023: Thumbi Ndung’u
por: Ndung’u, Thumbi
Publicado: (2023)

HIV specific CD8(+) T(RM)-like cells in tonsils express exhaustive signatures in the absence of natural HIV control
por: Fardoos, Rabiah, et al.
Publicado: (2022)

Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens
por: Meermeier, Erin W., et al.
Publicado: (2016)

HIV-1 vaccine immunogen design strategies
por: Mann, Jaclyn K, et al.
Publicado: (2015)

The potential of lactoferrin, ovotransferrin and lysozyme as antiviral and immune-modulating agents in COVID-19
por: Mann, Jaclyn Kelly, et al.
Publicado: (2020)

Prevalence and seasonality of common viral respiratory pathogens, including Cytomegalovirus in children, between 0–5 years of age in KwaZulu-Natal, an HIV endemic province in South Africa
por: Famoroti, Temitayo, et al.
Publicado: (2018)

HIV status alters disease severity and immune cell responses in Beta variant SARS-CoV-2 infection wave
por: Karim, Farina, et al.
Publicado: (2021)

Early clearance versus control: what is the meaning of a negative tuberculin skin test or interferon-gamma release assay following exposure to Mycobacterium tuberculosis?
por: Meermeier, Erin W., et al.
Publicado: (2018)

COVID-19 in Africa: preexisting immunity and HIV
por: Snyman, Jumari, et al.
Publicado: (2021)

Irreversible depletion of intestinal CD4(+) T cells is associated with T cell activation during chronic HIV infection
por: Asowata, Osaretin E., et al.
Publicado: (2021)

Pulmonary hypertension: Spectrum of disease, clinical presentation and treatment outcomes at the main respiratory pulmonary hypertension clinic in KwaZulu-Natal Province, South Africa
por: Dahim, M, et al.
Publicado: (2021)

Human thymic MR1-restricted MAIT cells are innate pathogen-reactive effectors that adapt following thymic egress
por: Gold, Marielle C., et al.
Publicado: (2012)

HIV skews the SARS-CoV-2 B cell response towards an extrafollicular maturation pathway
por: Krause, Robert, et al.
Publicado: (2022)

High-Frequency, Functional HIV-Specific T-Follicular Helper and Regulatory Cells Are Present Within Germinal Centers in Children but Not Adults
por: Roider, Julia, et al.
Publicado: (2018)

Innate Lymphoid Cell Activation and Sustained Depletion in Blood and Tissue of Children Infected with HIV from Birth Despite Antiretroviral Therapy
por: Singh, Alveera, et al.
Publicado: (2020)

Genetic determinants of Nef-mediated CD4 and HLA class I down-regulation differences between HIV-1 subtypes B and C
por: Mann, Jaclyn K., et al.
Publicado: (2015)

MAIT cells and viruses
por: Ussher, James E, et al.
Publicado: (2018)

MAIT cells and the microbiome
por: Jabeen, Maisha F., et al.
Publicado: (2023)

Co-Infection with Mycobacterium tuberculosis Impairs HIV-Specific CD8+ and CD4+ T Cell Functionality
por: Chetty, Shivan, et al.
Publicado: (2015)

MicroRNA-155 Regulates MAIT1 and MAIT17 Cell Differentiation
por: Liu, Tingting, et al.
Publicado: (2021)

Augmentation of the Riboflavin-Biosynthetic Pathway Enhances Mucosa-Associated Invariant T (MAIT) Cell Activation and Diminishes Mycobacterium tuberculosis Virulence
por: Dey, Ruchi Jain, et al.
Publicado: (2022)

Quantitative and Qualitative Perturbations of CD8(+) MAITs in Healthy Mycobacterium tuberculosis–Infected Individuals
por: Pomaznoy, Mikhail, et al.
Publicado: (2020)

Bone marrow stromal antigen 2 (BST-2) genetic variants influence expression levels and disease outcome in HIV-1 chronically infected patients
por: Mlimi, Hlelolwenkosi, et al.
Publicado: (2022)

MAIT cells: the end of the beginning?
por: Pellicci, Daniel G, et al.
Publicado: (2018)

MAIT cells in metabolic diseases
por: Bertrand, Léo, et al.
Publicado: (2019)

MAIT Cell Activation and Functions
por: Hinks, Timothy S. C., et al.
Publicado: (2020)

Divergent metabolic programmes control two populations of MAIT cells that protect the lung
por: Riffelmacher, Thomas, et al.
Publicado: (2023)

Monkeying around with MAIT Cells: Studying the Role of MAIT Cells in SIV and Mtb Co-Infection
por: Moriarty, Ryan V., et al.
Publicado: (2021)

Endosomal MR1 Trafficking Plays a Key Role in Presentation of Mycobacterium tuberculosis Ligands to MAIT Cells
por: Harriff, Melanie J., et al.
Publicado: (2016)

MR1-restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usage
por: Gold, Marielle C., et al.
Publicado: (2014)

Relationship of Human Immunodeficiency Virus Viral Load in Cerebrospinal Fluid and Plasma in Patients Co-infected With Cryptococcal Meningitis
por: Chang, Christina C., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_v3m8ce5itp2ah5o7b370m18gba