Re-wiring the regulation of the formicamycin biosynthetic gene cluster to enable the development of promising antibacterial compounds

The formicamycins are promising antibiotics first identified in Streptomyces formicae KY5, which produces the compounds at low levels. Here, we show that by understanding the regulation of the for biosynthetic gene cluster (BGC), we can rewire the BGC to increase production levels. The for BGC consi...

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Detalles Bibliográficos
Autores principales: Devine, Rebecca, McDonald, Hannah P., Qin, Zhiwei, Arnold, Corinne J., Noble, Katie, Chandra, Govind, Wilkinson, Barrie, Hutchings, Matthew I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062789/
https://www.ncbi.nlm.nih.gov/pubmed/33440167
http://dx.doi.org/10.1016/j.chembiol.2020.12.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062789/
https://www.ncbi.nlm.nih.gov/pubmed/33440167
http://dx.doi.org/10.1016/j.chembiol.2020.12.011

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