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High-resolution quantitative profiling of tRNA abundance and modification status in eukaryotes by mim-tRNAseq
Measurements of cellular tRNA abundance are hampered by pervasive blocks to cDNA synthesis at modified nucleosides and the extensive similarity among tRNA genes. We overcome these limitations with modification-induced misincorporation tRNA sequencing (mim-tRNAseq), which combines a workflow for full...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062790/ https://www.ncbi.nlm.nih.gov/pubmed/33581077 http://dx.doi.org/10.1016/j.molcel.2021.01.028 |