Hydroxyurea affects in vitro porcine oocyte maturation through increased apoptosis and oxidative stress

Hydroxyurea (HU) is an FDA-approved drug used to treat a variety of diseases, especially malignancies, but is harmful to fertility. We used porcine oocytes as an experimental model to study the effect of HU during oocyte maturation. Exposure of cumulus–oocyte complexes (COCs) to 20 µM (P<0.01) an...

Descripción completa

Detalles Bibliográficos
Autores principales: Gao, Wei, Jin, Yongxun, Hao, Jindong, Huang, Siyi, Wang, Dongxu, Quan, Fushi, Zhang, Mingjun, Zhang, Jiabao, Ren, Wenzhi, Yu, Xianfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2021
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062957/
https://www.ncbi.nlm.nih.gov/pubmed/33844009
http://dx.doi.org/10.1042/BSR20203091

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062957/
https://www.ncbi.nlm.nih.gov/pubmed/33844009
http://dx.doi.org/10.1042/BSR20203091

Ejemplares similares