The E3 ubiquitin ligase SCF(Fbxo7) mediates proteasomal degradation of UXT isoform 2 (UXT-V2) to inhibit the NF-κB signaling pathway

BACKGROUND: Ubiquitously eXpressed Transcript isoform 2 (UXT—V2) is a prefoldin-like protein involved in NF-κB signaling, apoptosis, and the androgen and estrogen response. UXT-V2 is a cofactor in the NF-κB transcriptional enhanceosome, and its knockdown inhibits TNF-α -induced NF-κB activation. Fbx...

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Detalles Bibliográficos
Autores principales: Spagnol, Valentine, Oliveira, Caio A.B., Randle, Suzanne J., Passos, Patrícia M.S., Correia, Camila R.S.T.B., Simaroli, Natália B., Oliveira, Joice S., Mevissen, Tycho E.T., Medeiros, Ana Carla, Gomes, Marcelo D., Komander, David, Laman, Heike, Teixeira, Felipe Roberti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8063000/
https://www.ncbi.nlm.nih.gov/pubmed/33010352
http://dx.doi.org/10.1016/j.bbagen.2020.129754

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8063000/
https://www.ncbi.nlm.nih.gov/pubmed/33010352
http://dx.doi.org/10.1016/j.bbagen.2020.129754

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