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Non-linear Normalization for Non-UMI Single Cell RNA-Seq
Single cell RNA-seq data, like data from other sequencing technology, contain systematic technical noise. Such noise results from a combined effect of unequal efficiencies in the capturing and counting of mRNA molecules, such as extraction/amplification efficiency and sequencing depth. We show that...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8063035/ https://www.ncbi.nlm.nih.gov/pubmed/33897755 http://dx.doi.org/10.3389/fgene.2021.612670 |