Enhanced detection of expanded repeat mRNA foci with hybridization chain reaction

Transcribed nucleotide repeat expansions form detectable RNA foci in patient cells that contribute to disease pathogenesis. The most widely used method for detecting RNA foci, fluorescence in situ hybridization (FISH), is powerful but can suffer from issues related to signal above background. Here w...

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Detalles Bibliográficos
Autores principales: Glineburg, M. Rebecca, Zhang, Yuan, Krans, Amy, Tank, Elizabeth M., Barmada, Sami J., Todd, Peter K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8063431/
https://www.ncbi.nlm.nih.gov/pubmed/33892814
http://dx.doi.org/10.1186/s40478-021-01169-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8063431/
https://www.ncbi.nlm.nih.gov/pubmed/33892814
http://dx.doi.org/10.1186/s40478-021-01169-8

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