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Enhanced detection of expanded repeat mRNA foci with hybridization chain reaction
Transcribed nucleotide repeat expansions form detectable RNA foci in patient cells that contribute to disease pathogenesis. The most widely used method for detecting RNA foci, fluorescence in situ hybridization (FISH), is powerful but can suffer from issues related to signal above background. Here w...
Autores principales: | Glineburg, M. Rebecca, Zhang, Yuan, Krans, Amy, Tank, Elizabeth M., Barmada, Sami J., Todd, Peter K. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8063431/ https://www.ncbi.nlm.nih.gov/pubmed/33892814 http://dx.doi.org/10.1186/s40478-021-01169-8 |
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