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Clonal Evolution of a High-Grade Pediatric Glioma With Distant Metastatic Spread
OBJECTIVE: High-grade glioma (HGG) rarely spreads outside the CNS. To test the hypothesis that the lesions were metastases originating from an HGG, we sequenced the relapsing HGG and distant extraneural lesions. METHODS: We performed whole-exome sequencing of an HGG lesion, its local relapse, and di...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Wolters Kluwer
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8063622/ https://www.ncbi.nlm.nih.gov/pubmed/33898738 http://dx.doi.org/10.1212/NXG.0000000000000561 |