Pathogenesis and pathology of anti-neutrophil cytoplasmic antibody（ANCA）-associated vasculitis

• AAV is characterized by necrotizing small vessel vasculitis with positive serum ANCA. • MPO/PR3-ANCA and neutrophils play central roles in AAV pathogenicity. • Dysregulated complement system primes neutrophils. • MPO-ANCA directly activates neutrophils to induce NETosis followed by releasing NETs....

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Detalles Bibliográficos
Autores principales: Tsukui, Daisuke, Kimura, Yoshitaka, Kono, Hajime
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Review article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8063861/
https://www.ncbi.nlm.nih.gov/pubmed/33912820
http://dx.doi.org/10.1016/j.jtauto.2021.100094
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author Tsukui, Daisuke
Kimura, Yoshitaka
Kono, Hajime
author_facet Tsukui, Daisuke
Kimura, Yoshitaka
Kono, Hajime
author_sort Tsukui, Daisuke
collection PubMed
description • AAV is characterized by necrotizing small vessel vasculitis with positive serum ANCA. • MPO/PR3-ANCA and neutrophils play central roles in AAV pathogenicity. • Dysregulated complement system primes neutrophils. • MPO-ANCA directly activates neutrophils to induce NETosis followed by releasing NETs. • B cells, T cells, and dendritic cells also contribute to the pathogenicity of AAV.
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spelling pubmed-80638612021-04-27 Pathogenesis and pathology of anti-neutrophil cytoplasmic antibody（ANCA）-associated vasculitis Tsukui, Daisuke Kimura, Yoshitaka Kono, Hajime J Transl Autoimmun Review article • AAV is characterized by necrotizing small vessel vasculitis with positive serum ANCA. • MPO/PR3-ANCA and neutrophils play central roles in AAV pathogenicity. • Dysregulated complement system primes neutrophils. • MPO-ANCA directly activates neutrophils to induce NETosis followed by releasing NETs. • B cells, T cells, and dendritic cells also contribute to the pathogenicity of AAV. Elsevier 2021-03-03 /pmc/articles/PMC8063861/ /pubmed/33912820 http://dx.doi.org/10.1016/j.jtauto.2021.100094 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review article
Tsukui, Daisuke
Kimura, Yoshitaka
Kono, Hajime
Pathogenesis and pathology of anti-neutrophil cytoplasmic antibody（ANCA）-associated vasculitis
title Pathogenesis and pathology of anti-neutrophil cytoplasmic antibody（ANCA）-associated vasculitis
title_full Pathogenesis and pathology of anti-neutrophil cytoplasmic antibody（ANCA）-associated vasculitis
title_fullStr Pathogenesis and pathology of anti-neutrophil cytoplasmic antibody（ANCA）-associated vasculitis
title_full_unstemmed Pathogenesis and pathology of anti-neutrophil cytoplasmic antibody（ANCA）-associated vasculitis
title_short Pathogenesis and pathology of anti-neutrophil cytoplasmic antibody（ANCA）-associated vasculitis
title_sort pathogenesis and pathology of anti-neutrophil cytoplasmic antibody（anca）-associated vasculitis
topic Review article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8063861/
https://www.ncbi.nlm.nih.gov/pubmed/33912820
http://dx.doi.org/10.1016/j.jtauto.2021.100094
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