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Pathogenesis and pathology of anti-neutrophil cytoplasmic antibody(ANCA)-associated vasculitis
• AAV is characterized by necrotizing small vessel vasculitis with positive serum ANCA. • MPO/PR3-ANCA and neutrophils play central roles in AAV pathogenicity. • Dysregulated complement system primes neutrophils. • MPO-ANCA directly activates neutrophils to induce NETosis followed by releasing NETs....
Autores principales: | Tsukui, Daisuke, Kimura, Yoshitaka, Kono, Hajime |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8063861/ https://www.ncbi.nlm.nih.gov/pubmed/33912820 http://dx.doi.org/10.1016/j.jtauto.2021.100094 |
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