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Regulation of translation by methylation multiplicity of 18S rRNA

SUMMARY: N(6)-methyladenosine (m(6)A) is a conserved ribonucleoside modification that regulates many facets of RNA metabolism. Using quantitative mass spectrometry, we find that the universally conserved tandem adenosines at the 3′ end of 18S rRNA, thought to be constitutively di-methylated (m(6)(2)...

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Detalles Bibliográficos
Autores principales: Liu, Kuanqing, Santos, Daniel A., Hussmann, Jeffrey A., Wang, Yun, Sutter, Benjamin M., Weissman, Jonathan S., Tu, Benjamin P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8063911/
https://www.ncbi.nlm.nih.gov/pubmed/33691096
http://dx.doi.org/10.1016/j.celrep.2021.108825