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The Telomeric Protein TRF2 Regulates Replication Origin Activity within Pericentromeric Heterochromatin

Heterochromatic regions render the replication process particularly difficult due to the high level of chromatin compaction and the presence of repeated DNA sequences. In humans, replication through pericentromeric heterochromatin requires the binding of a complex formed by the telomeric factor TRF2...

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Detalles Bibliográficos
Autores principales: Bauwens, Serge, Lototska, Liudmyla, Koundrioukoff, Stephane, Debatisse, Michelle, Ye, Jing, Gilson, Eric, Mendez-Bermudez, Aaron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8063955/
https://www.ncbi.nlm.nih.gov/pubmed/33804994
http://dx.doi.org/10.3390/life11040267