Acquired HIV-1 Protease Conformational Flexibility Associated with Lopinavir Failure May Shape the Outcome of Darunavir Therapy after Antiretroviral Therapy Switch

Understanding the underlying molecular interaction during a therapy switch from lopinavir (LPV) to darunavir (DRV) is essential to achieve long-term virological suppression. We investigated the kinetic and structural characteristics of multidrug-resistant South African HIV-1 subtype C protease (HIV-...

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Detalles Bibliográficos
Autores principales: Eche, Simeon, Kumar, Ajit, Sonela, Nelson, Gordon, Michelle L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064090/
https://www.ncbi.nlm.nih.gov/pubmed/33805099
http://dx.doi.org/10.3390/biom11040489

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064090/
https://www.ncbi.nlm.nih.gov/pubmed/33805099
http://dx.doi.org/10.3390/biom11040489

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