IL-21 Receptor Blockade Shifts the Follicular T Cell Balance and Reduces De Novo Donor-Specific Antibody Generation

Donor-specific antibodies (DSAs) play a key role in chronic kidney allograft injury. Follicular T helper (Tfh) cells trigger the humoral alloimmune response and promote DSA generation, while T-follicular regulatory (Tfr) cells inhibit antibody production by suppressing Tfh and B cells. Interleukin (...

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Detalles Bibliográficos
Autores principales: Nian, Yeqi, Xiong, Zhilei, Zhan, Panpan, Wang, Zhen, Xu, Yang, Wei, Jianghao, Zhao, Jie, Fu, Yingxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064115/
https://www.ncbi.nlm.nih.gov/pubmed/33897706
http://dx.doi.org/10.3389/fimmu.2021.661580

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064115/
https://www.ncbi.nlm.nih.gov/pubmed/33897706
http://dx.doi.org/10.3389/fimmu.2021.661580

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