Cargando…

BMP5 silencing inhibits chondrocyte senescence and apoptosis as well as osteoarthritis progression in mice

In this study, we using the in vivo destabilization of the medial meniscus (DMM) mouse model to investigate the role of bone morphogenetic protein 5 (BMP5) in osteoarthritis (OA) progression mediated via chondrocyte senescence and apoptosis. BMP5 expression was significantly higher in knee articular...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shao, Yan, Zhao, Chang, Pan, Jianying, Zeng, Chun, Zhang, Hongbo, Liu, Liangliang, Fan, Kai, Liu, Xin, Luo, Bingsheng, Fang, Hang, Bai, Xiaochun, Zhang, Haiyan, Cai, Daozhang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064147/ https://www.ncbi.nlm.nih.gov/pubmed/33744859 http://dx.doi.org/10.18632/aging.202708

Ejemplares similares

MFG-E8 regulated by miR-99b-5p protects against osteoarthritis by targeting chondrocyte senescence and macrophage reprogramming via the NF-κB pathway
por: Lu, Yuheng, et al.
Publicado: (2021)

Fargesin ameliorates osteoarthritis via macrophage reprogramming by downregulating MAPK and NF-κB pathways
por: Lu, Jiansen, et al.
Publicado: (2021)

MiR-146b accelerates osteoarthritis progression by targeting alpha-2-macroglobulin
por: Liu, Xin, et al.
Publicado: (2019)

Metformin attenuates cartilage degeneration in an experimental osteoarthritis model by regulating AMPK/mTOR
por: Feng, Xiaofeng, et al.
Publicado: (2020)

Pentraxin 3 regulated by miR-224-5p modulates macrophage reprogramming and exacerbates osteoarthritis associated synovitis by targeting CD32
por: Yin, Jianbin, et al.
Publicado: (2022)

Down-regulated GAS6 impairs synovial macrophage efferocytosis and promotes obesity-associated osteoarthritis
por: Yao, Zihao, et al.
Publicado: (2023)

Activation of mTORC1 in subchondral bone preosteoblasts promotes osteoarthritis by stimulating bone sclerosis and secretion of CXCL12
por: Lin, Chuangxin, et al.
Publicado: (2019)

Chondrocyte Apoptosis in the Pathogenesis of Osteoarthritis
por: Hwang, Hyun Sook, et al.
Publicado: (2015)

Correction to: Activation of mTORC1 in subchondral bone preosteoblasts promotes osteoarthritis by stimulating bone sclerosis and secretion of CXCL12
por: Lin, Chuangxin, et al.
Publicado: (2019)

The Role of Chondrocyte Hypertrophy and Senescence in Osteoarthritis Initiation and Progression
por: Rim, Yeri Alice, et al.
Publicado: (2020)

Sirt6 attenuates chondrocyte senescence and osteoarthritis progression
por: Ji, Ming-liang, et al.
Publicado: (2022)

OPN Deficiency Increases the Severity of Osteoarthritis Associated with Aberrant Chondrocyte Senescence and Apoptosis and Upregulates the Expression of Osteoarthritis-Associated Genes
por: Tian, Jian, et al.
Publicado: (2020)

Biomarkers of Chondrocyte Apoptosis and Autophagy in Osteoarthritis
por: Musumeci, Giuseppe, et al.
Publicado: (2015)

Fructose-bisphosphatase1 (FBP1) alleviates experimental osteoarthritis by regulating Protein crumbs homolog 3 (CRB3)
por: Wang, Zhuolun, et al.
Publicado: (2023)

RIP1 Perturbation Induces Chondrocyte Necroptosis and Promotes Osteoarthritis Pathogenesis via Targeting BMP7
por: Cheng, Jin, et al.
Publicado: (2021)

Wnt/β-catenin signaling may induce senescence of chondrocytes in osteoarthritis
por: Li, Weijun, et al.
Publicado: (2020)

High TRB3 expression induces chondrocyte autophagy and senescence in osteoarthritis cartilage
por: Gu, Yanqing, et al.
Publicado: (2022)

Inflammatory and Metabolic Signaling Interfaces of the Hypertrophic and Senescent Chondrocyte Phenotypes Associated with Osteoarthritis
por: Horváth, Emőke, et al.
Publicado: (2023)

A comprehensive analysis of biomarkers associated with synovitis and chondrocyte apoptosis in osteoarthritis
por: Yang, Ling, et al.
Publicado: (2023)

Role of GDF15/MAPK14 Axis in Chondrocyte Senescence as a Novel Senomorphic Agent in Osteoarthritis
por: Weng, Pei-Wei, et al.
Publicado: (2022)

Anti-chondrocyte apoptosis effect of genistein in treating inflammation-induced osteoarthritis
por: Zou, Yang, et al.
Publicado: (2020)

mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation
por: Yan, Bo, et al.
Publicado: (2016)

Bax Targeted by miR-29a Regulates Chondrocyte Apoptosis in Osteoarthritis
por: Miao, Guiqiang, et al.
Publicado: (2019)

Distinct metabolic programs induced by TGF-β1 and BMP2 in human articular chondrocytes with osteoarthritis
por: Wang, Cuicui, et al.
Publicado: (2018)

Gremlin-1 and BMP-4 Overexpressed in Osteoarthritis Drive an Osteochondral-Remodeling Program in Osteoblasts and Hypertrophic Chondrocytes
por: Pérez-Lozano, Maria-Luisa, et al.
Publicado: (2022)

IRE1 signaling regulates chondrocyte apoptosis and death fate in the osteoarthritis
por: Huang, Rongxiang, et al.
Publicado: (2021)

Monotropein attenuates apoptosis and pyroptosis in chondrocytes and alleviates osteoarthritis progression in mice
por: Li, Zhen, et al.
Publicado: (2023)

miR-140 Attenuates the Progression of Early-Stage Osteoarthritis by Retarding Chondrocyte Senescence
por: Si, Hai-bo, et al.
Publicado: (2019)

Influence of protein kinase RIPK4 expression on the apoptosis and proliferation of chondrocytes in osteoarthritis
por: Zou, Lixue, et al.
Publicado: (2018)

BMP7 reduces the fibrocartilage chondrocyte phenotype
por: Ripmeester, Ellen G. J., et al.
Publicado: (2021)

Navitoclax (ABT263) reduces inflammation and promotes chondrogenic phenotype by clearing senescent osteoarthritic chondrocytes in osteoarthritis
por: Yang, Hao, et al.
Publicado: (2020)

MYL3 protects chondrocytes from senescence by inhibiting clathrin-mediated endocytosis and activating of Notch signaling
por: Cao, He, et al.
Publicado: (2023)

Regulation of α5 and αV Integrin Expression by GDF-5 and BMP-7 in Chondrocyte Differentiation and Osteoarthritis
por: Garciadiego-Cázares, David, et al.
Publicado: (2015)

Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function
por: Yudoh, Kazuo, et al.
Publicado: (2005)

Bioinformatic analysis reveals potential relationship between chondrocyte senescence and protein glycosylation in osteoarthritis pathogenesis
por: Yoshimoto, Makoto, et al.
Publicado: (2023)

LINC00623/miR-101/HRAS axis modulates IL-1β-mediated ECM degradation, apoptosis and senescence of osteoarthritis chondrocytes
por: Lü, Guohua, et al.
Publicado: (2020)

Selective COX-2 inhibitor ameliorates osteoarthritis by repressing apoptosis of chondrocyte
por: Ou, Yunsheng, et al.
Publicado: (2012)

Aquaporin 1 contributes to chondrocyte apoptosis in a rat model of osteoarthritis
por: Gao, Hangfei, et al.
Publicado: (2016)

Glycolytic enzyme PKM2 regulates cell senescence but not inflammation in the process of osteoarthritis: PKM2 regulates chondrocyte senescence via p16 (INK4a) transcription
por: Liu, Bo, et al.
Publicado: (2023)

Anti-Dlx5 Retards the Progression of Osteoarthritis through Inhibiting Chondrocyte Hypertrophy and Apoptosis
por: Lu, Ye, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_pl8rne9s40ilejbl00mgfn8ng8