Inhibition of HDAC6 by Tubastatin A reduces chondrocyte oxidative stress in chondrocytes and ameliorates mouse osteoarthritis by activating autophagy

The aim of this study was to determine the effect of HDAC6 inhibition using the selective inhibitor Tubastatin A (TubA) on the regulation of tert-butyl hydroperoxide (TBHP)-treated chondrocytes and a mouse OA model. Using conventional molecular biology methods, our results showed that the level of H...

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Detalles Bibliográficos
Autores principales: Shen, Zhonghai, Ji, Kang, Cai, Zhenhai, Huang, Chenglong, He, Xiaojun, Xu, Hongwei, Chen, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064156/
https://www.ncbi.nlm.nih.gov/pubmed/33744850
http://dx.doi.org/10.18632/aging.202736

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064156/
https://www.ncbi.nlm.nih.gov/pubmed/33744850
http://dx.doi.org/10.18632/aging.202736

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