Cargando…

Design and Synthesis of Novel Symmetric Fluorene-2,7-Diamine Derivatives as Potent Hepatitis C Virus Inhibitors

Hepatitis C virus (HCV) is an international challenge. Since the discovery of NS5A direct-acting antivirals, researchers turned their attention to pursue novel NS5A inhibitors with optimized design and structure. Herein we explore highly potent hepatitis C virus (HCV) NS5A inhibitors; the novel anal...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mousa, Mai H. A., Ahmed, Nermin S., Schwedtmann, Kai, Frakolaki, Efseveia, Vassilaki, Niki, Zoidis, Grigoris, Weigand, Jan J., Abadi, Ashraf H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064491/ https://www.ncbi.nlm.nih.gov/pubmed/33806139 http://dx.doi.org/10.3390/ph14040292

Ejemplares similares

Symmetric Anti-HCV Agents: Synthesis, Antiviral Properties, and Conformational Aspects of Core Scaffolds
por: Leila, Alaa R. S., et al.
Publicado: (2019)

Design and Synthesis of Novel Bis-Imidazolyl Phenyl Butadiyne Derivatives as HCV NS5A Inhibitors
por: Hamdy, Jehad, et al.
Publicado: (2022)

A Novel Cis-Acting RNA Structural Element Embedded in the Core Coding Region of the Hepatitis C Virus Genome Directs Internal Translation Initiation of the Overlapping Core+1 ORF
por: Vassilaki, Niki, et al.
Publicado: (2020)

Novel Lipophilic Hydroxamates Based on Spirocarbocyclic Hydantoin Scaffolds with Potent Antiviral and Trypanocidal Activity
por: Pardali, Vasiliki, et al.
Publicado: (2023)

Emerging Role of l-Dopa Decarboxylase in Flaviviridae Virus Infections
por: Frakolaki, Efseveia, et al.
Publicado: (2019)

New Affordable Methods for Large-Scale Isolation of Major Olive Secoiridoids and Systematic Comparative Study of Their Antiproliferative/Cytotoxic Effect on Multiple Cancer Cell Lines of Different Cancer Origins
por: Papakonstantinou, Aikaterini, et al.
Publicado: (2022)

Dengue Virus Replication Is Associated with Catecholamine Biosynthesis and Metabolism in Hepatocytes
por: Mpekoulis, George, et al.
Publicado: (2022)

Association of Hepatitis C Virus Replication with the Catecholamine Biosynthetic Pathway
por: Mpekoulis, George, et al.
Publicado: (2021)

The Role of Tissue Oxygen Tension in Dengue Virus Replication
por: Frakolaki, Efseveia, et al.
Publicado: (2018)

Structure–Activity Relationships of Triphenylethylene Derivatives and Their Evaluation as Anticancer and Antiviral Agents
por: Ahmed, Nermin S., et al.
Publicado: (2023)

Alteration of L-Dopa decarboxylase expression in SARS-CoV-2 infection and its association with the interferon-inducible ACE2 isoform
por: Mpekoulis, George, et al.
Publicado: (2021)

Novel 6-Aminoquinazolinone Derivatives as Potential Cross GT1-4 HCV NS5B Inhibitors
por: Nasr, Tamer, et al.
Publicado: (2022)

2,7-Dichloro-4-(chloroacetyl)fluorene
por: Chu, Jian-Bo, et al.
Publicado: (2009)

Manipulating Estrogenic/Anti-Estrogenic Activity of Triphenylethylenes towards Development of Novel Anti-Neoplastic SERMs
por: Elnakib, Heba E., et al.
Publicado: (2021)

2,7-Dibromo-9,9-dimethyl-9H-fluorene
por: Chen, Xiao, et al.
Publicado: (2010)

Novel Lipophilic Acetohydroxamic Acid Derivatives Based on Conformationally Constrained Spiro Carbocyclic 2,6-Diketopiperazine Scaffolds with Potent Trypanocidal Activity
por: Fytas, Christos, et al.
Publicado: (2011)

Bioactive fluorenes. Part III: 2,7-dichloro-9H-fluorene-based thiazolidinone and azetidinone analogues as anticancer and antimicrobial against multidrug resistant strains agents
por: Hussein, Essam M., et al.
Publicado: (2020)

N (2)-(7-Bromo-9-butyl-9H-carbazol-2-yl)-9,9-diethyl-N (2),N (7),N (7)-triphenyl-9H-fluorene-2,7-diamine
por: Baheti, Abhishek, et al.
Publicado: (2012)

2-Dibutylamino-1-(2,7-dichloro-9H-fluoren-4-yl)ethanol
por: Fun, Hoong-Kun, et al.
Publicado: (2010)

The Hydroxylation of Fluorene in the Rat and the Rabbit
por: Dewhurst, F.
Publicado: (1962)

Fluoren-9-one oxime
por: Bugenhagen, Bernhard, et al.
Publicado: (2014)

Synthesis of New C(2)-Symmetric Fluoren-9-ylidene Malonate Derived Bis(oxazoline) Ligands and Their Application in Friedel-Crafts Reactions
por: Li, Jing, et al.
Publicado: (2010)

Development of Stilbenoid and Chalconoid Analogues as Potent Tyrosinase Modulators and Antioxidant Agents
por: Vontzalidou, Argyro, et al.
Publicado: (2022)

Benzo[a]fluoren-11-one
por: Sun, Di, et al.
Publicado: (2008)

Recent Advances in Hepatitis B Treatment
por: Prifti, Georgia-Myrto, et al.
Publicado: (2021)

9-Chloromethyl-9-[(9H-fluoren-9-yl)methyl]-9H-fluorene
por: Shen, Qun, et al.
Publicado: (2008)

2,7-Dibromo-9,9-bis[(pyridin-1-ium-4-yl)methyl]fluorene dinitrate
por: Jian, Fang-Fang, et al.
Publicado: (2010)

4,4′-[(2,7-Dibromofluorene-9,9-diyl)dimethylene]dipyridinium bis(perchlorate)
por: Xuan, Zongwei, et al.
Publicado: (2010)

Targeting Metalloenzymes: The “Achilles’ Heel” of Viruses and Parasites
por: Moianos, Dimitrios, et al.
Publicado: (2023)

Synthesis and Characterization of Organo-Soluble Polyimides Based on Polycondensation Chemistry of Fluorene-Containing Dianhydride and Amide-Bridged Diamines with Good Optical Transparency and Glass Transition Temperatures over 400 °C
por: Ren, Xi, et al.
Publicado: (2023)

Fluorene derivatives in rats bearing Walker carcinosarcoma.
por: Malejka, D.
Publicado: (1965)

3,9′-Bi(9H-fluorene)
por: Liu, Jie, et al.
Publicado: (2012)

High Fluorescent Porphyrin-PAMAM-Fluorene Dendrimers
por: Garfias-Gonzalez, Karla I., et al.
Publicado: (2015)

Fluorene‐containing tetraphenylethylene molecules as lasing materials
por: Orofino, C., et al.
Publicado: (2016)

Terthiophene Functionalized Conjugated Triarm Polymers Containing Poly(fluorene-2,7-vinylene) Arms Having Different Cores—Synthesis and Their Unique Optical Properties
por: Nomura, Kotohiro, et al.
Publicado: (2018)

Effect of Rapid Tissue Growth on the Uptake of Fluorene-2,7-Di-(Sulfonamido-2-Naphthalene)-S(35) by the Liver and Spleen of Rats and Hamsters
por: Argus, Mary F., et al.
Publicado: (1962)

Bioactive fluorenes. part I. Synthesis, pharmacological study and molecular docking of novel dihydrofolate reductase inhibitors based-2,7-dichlorofluorene
por: Hussein, Essam M., et al.
Publicado: (2019)

Coordination Chemistry and Methylation of Mixed‐Substituted Tetraphosphetanes (RP−PtBu)(2) (R=Ph, Py)
por: Schoemaker, Robin, et al.
Publicado: (2020)

Fluorene benzothiadiazole co-oligomer based aqueous self-assembled nanoparticles
por: Schill, J., et al.
Publicado: (2020)

9-Allyl-9H-fluoren-9-ol
por: Knight, Kyle S., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_6n9lrjvo9331gsa84mlr42vg94