Reconstitution of cargo-induced LC3 lipidation in mammalian selective autophagy

Selective autophagy of damaged mitochondria, protein aggregates, and other cargoes is essential for health. Cargo initiates phagophore biogenesis, which entails the conjugation of LC3 to phosphatidylethanolamine. Current models suggest that clustered ubiquitin chains on a cargo trigger a cascade fro...

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Detalles Bibliográficos
Autores principales: Chang, Chunmei, Shi, Xiaoshan, Jensen, Liv E., Yokom, Adam L., Fracchiolla, Dorotea, Martens, Sascha, Hurley, James H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064641/
https://www.ncbi.nlm.nih.gov/pubmed/33893090
http://dx.doi.org/10.1126/sciadv.abg4922

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064641/
https://www.ncbi.nlm.nih.gov/pubmed/33893090
http://dx.doi.org/10.1126/sciadv.abg4922

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