Exceptional stability of a perilipin on lipid droplets depends on its polar residues, suggesting multimeric assembly

Numerous proteins target lipid droplets (LDs) through amphipathic helices (AHs). It is generally assumed that AHs insert bulky hydrophobic residues in packing defects at the LD surface. However, this model does not explain the targeting of perilipins, the most abundant and specific amphipathic prote...

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Detalles Bibliográficos
Autores principales: Giménez-Andrés, Manuel, Emeršič, Tadej, Antoine-Bally, Sandra, D'Ambrosio, Juan Martin, Antonny, Bruno, Derganc, Jure, Čopič, Alenka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064757/
https://www.ncbi.nlm.nih.gov/pubmed/33856341
http://dx.doi.org/10.7554/eLife.61401

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064757/
https://www.ncbi.nlm.nih.gov/pubmed/33856341
http://dx.doi.org/10.7554/eLife.61401

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