Nine residues in HLA-DQ molecules determine with susceptibility and resistance to type 1 diabetes among young children in Sweden

HLA-DQ molecules account over 50% genetic risk of type 1 diabetes (T1D), but little is known about associated residues. Through next generation targeted sequencing technology and deep learning of DQ residue sequences, the aim was to uncover critical residues and their motifs associated with T1D. Our...

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Detalles Bibliográficos
Autores principales: Zhao, Lue Ping, Papadopoulos, George K., Moustakas, Antonis K., Bondinas, George P., Carlsson, Annelie, Larsson, Helena Elding, Ludvigsson, Johnny, Marcus, Claude, Persson, Martina, Samuelsson, Ulf, Wang, Ruihan, Pyo, Chul-Woo, Geraghty, Daniel E., Lernmark, Åke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065060/
https://www.ncbi.nlm.nih.gov/pubmed/33893332
http://dx.doi.org/10.1038/s41598-021-86229-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065060/
https://www.ncbi.nlm.nih.gov/pubmed/33893332
http://dx.doi.org/10.1038/s41598-021-86229-8

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