VPS39-deficiency observed in type 2 diabetes impairs muscle stem cell differentiation via altered autophagy and epigenetics

Insulin resistance and lower muscle quality (strength divided by mass) are hallmarks of type 2 diabetes (T2D). Here, we explore whether alterations in muscle stem cells (myoblasts) from individuals with T2D contribute to these phenotypes. We identify VPS39 as an important regulator of myoblast diffe...

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Detalles Bibliográficos
Autores principales: Davegårdh, Cajsa, Säll, Johanna, Benrick, Anna, Broholm, Christa, Volkov, Petr, Perfilyev, Alexander, Henriksen, Tora Ida, Wu, Yanling, Hjort, Line, Brøns, Charlotte, Hansson, Ola, Pedersen, Maria, Würthner, Jens U., Pfeffer, Klaus, Nilsson, Emma, Vaag, Allan, Stener-Victorin, Elisabet, Pircs, Karolina, Scheele, Camilla, Ling, Charlotte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065135/
https://www.ncbi.nlm.nih.gov/pubmed/33893273
http://dx.doi.org/10.1038/s41467-021-22068-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065135/
https://www.ncbi.nlm.nih.gov/pubmed/33893273
http://dx.doi.org/10.1038/s41467-021-22068-5

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