Cargando…
VPS39-deficiency observed in type 2 diabetes impairs muscle stem cell differentiation via altered autophagy and epigenetics
Insulin resistance and lower muscle quality (strength divided by mass) are hallmarks of type 2 diabetes (T2D). Here, we explore whether alterations in muscle stem cells (myoblasts) from individuals with T2D contribute to these phenotypes. We identify VPS39 as an important regulator of myoblast diffe...
Autores principales: | Davegårdh, Cajsa, Säll, Johanna, Benrick, Anna, Broholm, Christa, Volkov, Petr, Perfilyev, Alexander, Henriksen, Tora Ida, Wu, Yanling, Hjort, Line, Brøns, Charlotte, Hansson, Ola, Pedersen, Maria, Würthner, Jens U., Pfeffer, Klaus, Nilsson, Emma, Vaag, Allan, Stener-Victorin, Elisabet, Pircs, Karolina, Scheele, Camilla, Ling, Charlotte |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065135/ https://www.ncbi.nlm.nih.gov/pubmed/33893273 http://dx.doi.org/10.1038/s41467-021-22068-5 |
Ejemplares similares
-
Sex influences DNA methylation and gene expression in human skeletal muscle myoblasts and myotubes
por: Davegårdh, Cajsa, et al.
Publicado: (2019) -
Circulating triglycerides are associated with human adipose tissue DNA methylation of genes linked to metabolic disease
por: Rönn, Tina, et al.
Publicado: (2023) -
A Single Bout of Electroacupuncture Remodels Epigenetic and Transcriptional Changes in Adipose Tissue in Polycystic Ovary Syndrome
por: Kokosar, Milana, et al.
Publicado: (2018) -
Abnormal epigenetic changes during differentiation of human skeletal muscle stem cells from obese subjects
por: Davegårdh, Cajsa, et al.
Publicado: (2017) -
Skeletal Muscle Immunometabolism in Women With Polycystic Ovary Syndrome: A Meta-Analysis
por: Manti, Maria, et al.
Publicado: (2020)