Elevated expression of the adhesion GPCR ADGRL4/ELTD1 promotes endothelial sprouting angiogenesis without activating canonical GPCR signalling

ADGRL4/ELTD1 is an orphan adhesion GPCR (aGPCR) expressed in endothelial cells that regulates tumour angiogenesis. The majority of aGPCRs are orphan receptors. The Stachel Hypothesis proposes a mechanism for aGPCR activation, in which aGPCRs contain a tethered agonist (termed Stachel) C-terminal to...

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Detalles Bibliográficos
Autores principales: Favara, David M., Liebscher, Ines, Jazayeri, Ali, Nambiar, Madhulika, Sheldon, Helen, Banham, Alison H., Harris, Adrian L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065136/
https://www.ncbi.nlm.nih.gov/pubmed/33893326
http://dx.doi.org/10.1038/s41598-021-85408-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065136/
https://www.ncbi.nlm.nih.gov/pubmed/33893326
http://dx.doi.org/10.1038/s41598-021-85408-x

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